Publications

Found 22 results
Filters: Keyword is Cations  [Clear All Filters]
2014
Cairns AG, Senn HMartin, Murphy MP & Hartley RC (2014) Expanding the palette of phenanthridinium cations. Chemistry 20, 3742-51
2010
Smith RAJ & Murphy MP (2010) Animal and human studies with the mitochondria-targeted antioxidant MitoQ. Ann N Y Acad Sci 1201, 96-103
Porteous CM, Logan A, Evans C, Ledgerwood EC, Menon DK, Aigbirhio F, Smith RAJ & Murphy MP (2010) Rapid uptake of lipophilic triphenylphosphonium cations by mitochondria in vivo following intravenous injection: implications for mitochondria-specific therapies and probes. Biochim Biophys Acta 1800, 1009-17
2008
Murata T, Yamato I, Kakinuma Y, Shirouzu M, Walker JE, Yokoyama S & Iwata S (2008) Ion binding and selectivity of the rotor ring of the Na+-transporting V-ATPase. Proc Natl Acad Sci U S A 105, 8607-12
Trnka J, Blaikie FH, Smith RAJ & Murphy MP (2008) A mitochondria-targeted nitroxide is reduced to its hydroxylamine by ubiquinol in mitochondria. Free Radic Biol Med 44, 1406-19
Ross MF, Prime TA, Abakumova I, James AM, Porteous CM, Smith RAJ & Murphy MP (2008) Rapid and extensive uptake and activation of hydrophobic triphenylphosphonium cations within cells. Biochem J 411, 633-45
Murphy MP (2008) Targeting lipophilic cations to mitochondria. Biochim Biophys Acta 1777, 1028-31
2007
Cochemé HM, Kelso GF, James AM, Ross MF, Trnka J, Mahendiran T, Asin-Cayuela J, Blaikie FH, Manas A-RB, Porteous CM, Adlam VJ, Smith RAJ & Murphy MP (2007) Mitochondrial targeting of quinones: therapeutic implications. Mitochondrion 7 Suppl, S94-102
Murphy MP & Smith RAJ (2007) Targeting antioxidants to mitochondria by conjugation to lipophilic cations. Annu Rev Pharmacol Toxicol 47, 629-56
2005
Ross MF, Kelso GF, Blaikie FH, James AM, Cochemé HM, Filipovska A, Da Ros T, Hurd TR, Smith RAJ & Murphy MP (2005) Lipophilic triphenylphosphonium cations as tools in mitochondrial bioenergetics and free radical biology. Biochemistry (Mosc) 70, 222-30
James AM, Cochemé HM & Murphy MP (2005) Mitochondria-targeted redox probes as tools in the study of oxidative damage and ageing. Mech Ageing Dev 126, 982-6
2003
Smith RAJ, Porteous CM, Gane AM & Murphy MP (2003) Delivery of bioactive molecules to mitochondria in vivo. Proc Natl Acad Sci U S A 100, 5407-12
Hirst J (2003) The dichotomy of complex I: a sodium ion pump or a proton pump. Proc Natl Acad Sci U S A 100, 773-5
James AM, Blaikie FH, Smith RAJ, Lightowlers RN, Smith PM & Murphy MP (2003) Specific targeting of a DNA-alkylating reagent to mitochondria. Synthesis and characterization of [4-((11aS)-7-methoxy-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-on-8-oxy)butyl]-triphenylphosphonium iodide. Eur J Biochem 270, 2827-36
2002
Lin T-K, Hughes G, Muratovska A, Blaikie FH, Brookes PS, Darley-Usmar V, Smith RAJ & Murphy MP (2002) Specific modification of mitochondrial protein thiols in response to oxidative stress: a proteomics approach. J Biol Chem 277, 17048-56
Echtay KS, Murphy MP, Smith RAJ, Talbot DA & Brand MD (2002) Superoxide activates mitochondrial uncoupling protein 2 from the matrix side. Studies using targeted antioxidants. J Biol Chem 277, 47129-35
2001
Murphy MP (2001) Development of lipophilic cations as therapies for disorders due to mitochondrial dysfunction. Expert Opin Biol Ther 1, 753-64
Muratovska A, Lightowlers RN, Taylor RW, Turnbull DM, Smith RA, Wilce JA, Martin SW & Murphy MP (2001) Targeting peptide nucleic acid (PNA) oligomers to mitochondria within cells by conjugation to lipophilic cations: implications for mitochondrial DNA replication, expression and disease. Nucleic Acids Res 29, 1852-63
1995
Raine AR, Yang CC, Packman LC, White SA, Mathews FS & Scrutton NS (1995) Protein recognition of ammonium cations using side-chain aromatics: a structural variation for secondary ammonium ligands. Protein Sci 4, 2625-8