Publications

Found 24 results
Filters: Keyword is Structure-Activity Relationship  [Clear All Filters]
2016
McCorvie TJ, Kopec J, Pey AL, Fitzpatrick F, Patel D, Chalk R, Shrestha L & Yue WW (2016) Molecular basis of classic galactosemia from the structure of human galactose 1-phosphate uridylyltransferase. Hum Mol Genet 25, 2234-2244
2014
Nicholls TJ & Minczuk M (2014) In D-loop: 40 years of mitochondrial 7S DNA. Exp Gerontol 56, 175-81
Dunn EA, Roxburgh M, Larsen L, Smith RAJ, McLellan AD, Heikal A, Murphy MP & Cook GM (2014) Incorporation of triphenylphosphonium functionality improves the inhibitory properties of phenothiazine derivatives in Mycobacterium tuberculosis. Bioorg Med Chem 22, 5320-8
Xu Y, Tao Y, Cheung LS, Fan C, Chen L-Q, Xu S, Perry K, Frommer WB & Feng L (2014) Structures of bacterial homologues of SWEET transporters in two distinct conformations. Nature 515, 448-452
2013
Narendra DP, Wang C, Youle RJ & Walker JE (2013) PINK1 rendered temperature sensitive by disease-associated and engineered mutations. Hum Mol Genet 22, 2572-89
2012
Efremov RG & Sazanov LA (2012) The coupling mechanism of respiratory complex I - a structural and evolutionary perspective. Biochim Biophys Acta 1817, 1785-95
Monné M, Miniero DValeria, Daddabbo L, Robinson AJ, Kunji ERS & Palmieri F (2012) Substrate specificity of the two mitochondrial ornithine carriers can be swapped by single mutation in substrate binding site. J Biol Chem 287, 7925-34
2010
Efremov RG, Baradaran R & Sazanov LA (2010) The architecture of respiratory complex I. Nature 465, 441-5
Narendra D, Kane LA, Hauser DN, Fearnley IM & Youle RJ (2010) p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both. Autophagy 6, 1090-106
2009
Yagi H, Konno H, Murakami-Fuse T, Isu A, Oroguchi T, Akutsu H, Ikeguchi M & Hisabori T (2009) Structural and functional analysis of the intrinsic inhibitor subunit epsilon of F1-ATPase from photosynthetic organisms. Biochem J 425, 85-94
Berrisford JM & Sazanov LA (2009) Structural basis for the mechanism of respiratory complex I. J Biol Chem 284, 29773-83
2007
Carbajo RJ, Kellas FA, Yang J-C, Runswick MJ, Montgomery MG, Walker JE & Neuhaus D (2007) How the N-terminal domain of the OSCP subunit of bovine F1Fo-ATP synthase interacts with the N-terminal region of an alpha subunit. J Mol Biol 368, 310-8
2004
Graziewicz MA, Longley MJ, Bienstock RJ, Zeviani M & Copeland WC (2004) Structure-function defects of human mitochondrial DNA polymerase in autosomal dominant progressive external ophthalmoplegia. Nat Struct Mol Biol 11, 770-6
Mamedova AA, Holt PJ, Carroll J & Sazanov LA (2004) Substrate-induced conformational change in bacterial complex I. J Biol Chem 279, 23830-6
Dafas P, Bolser D, Gomoluch J, Park J & Schroeder M (2004) Using convex hulls to extract interaction interfaces from known structures. Bioinformatics 20, 1486-90
2003
Zhang N, Chen H-M, Koch V, Schmitz H, Minczuk M, Stepien P, Fattom AI, Naso RB, Kalicharran K, Borowski P & Hosmane RS (2003) Potent inhibition of NTPase/helicase of the West Nile Virus by ring-expanded ("fat") nucleoside analogues. J Med Chem 46, 4776-89
Echtay KS, Esteves TC, Pakay JL, Jekabsons MB, Lambert AJ, Portero-Otín M, Pamplona R, Vidal-Puig AJ, Wang S, Roebuck SJ & Brand MD (2003) A signalling role for 4-hydroxy-2-nonenal in regulation of mitochondrial uncoupling. EMBO J 22, 4103-10
2000
Gibbons C, Montgomery MG, Leslie AG & Walker JE (2000) The structure of the central stalk in bovine F(1)-ATPase at 2.4 A resolution. Nat Struct Biol 7, 1055-61
1997
Matsui T, Muneyuki E, Honda M, Allison WS, Dou C & Yoshida M (1997) Catalytic activity of the alpha3beta3gamma complex of F1-ATPase without noncatalytic nucleotide binding site. J Biol Chem 272, 8215-21
Noji H, Yasuda R, Yoshida M & Kinosita K (1997) Direct observation of the rotation of F1-ATPase. Nature 386, 299-302