Publications

Found 82 results
Filters: Keyword is Mitochondria, Heart  [Clear All Filters]
2018
Agip A-NA, Blaza JN, Bridges HR, Viscomi C, Rawson S, Muench SP & Hirst J (2018) Cryo-EM structures of complex I from mouse heart mitochondria in two biochemically defined states. Nat Struct Mol Biol 25, 548-556
2017
Nesci S, Trombetti F, Ventrella V, Pirini M & Pagliarani A (2017) Kinetic properties of the mitochondrial F1FO-ATPase activity elicited by Ca(2+) in replacement of Mg(2). Biochimie 140, 73-81
2016
Mammucari C, Raffaello A, Reane DVecellio & Rizzuto R (2016) Molecular structure and pathophysiological roles of the Mitochondrial Calcium Uniporter. Biochim Biophys Acta 1863, 2457-64
Zhu J, Vinothkumar KR & Hirst J (2016) Structure of mammalian respiratory complex I. Nature 536, 354-8
2015
Yancey DM, Guichard JL, Ahmed MI, Zhou L, Murphy MP, Johnson MS, Benavides GA, Collawn J, Darley-Usmar V & Dell'Italia LJ (2015) Cardiomyocyte mitochondrial oxidative stress and cytoskeletal breakdown in the heart with a primary volume overload. Am J Physiol Heart Circ Physiol 308, H651-63
Dare AJ, Logan A, Prime TA, Rogatti S, Goddard M, Bolton EM, J Bradley A, Pettigrew GJ, Murphy MP & Saeb-Parsy K (2015) The mitochondria-targeted anti-oxidant MitoQ decreases ischemia-reperfusion injury in a murine syngeneic heart transplant model. J Heart Lung Transplant 34, 1471-80
2014
Vinothkumar KR, Zhu J & Hirst J (2014) Architecture of mammalian respiratory complex I. Nature 515, 80-84
Chouchani ET, Methner C, Buonincontri G, Hu C-H, Logan A, Sawiak SJ, Murphy MP & Krieg T (2014) Complex I deficiency due to selective loss of Ndufs4 in the mouse heart results in severe hypertrophic cardiomyopathy. PLoS One 9, e94157
Pulliam DA, Deepa SS, Liu Y, Hill S, Lin A-L, Bhattacharya A, Shi Y, Sloane L, Viscomi C, Zeviani M & Van Remmen H (2014) Complex IV-deficient Surf1(-/-) mice initiate mitochondrial stress responses. Biochem J 462, 359-71
Bridges HR, J Y Jones A, Pollak MN & Hirst J (2014) Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria. Biochem J 462, 475-87
Blaza JN, Serreli R, J Y Jones A, Mohammed K & Hirst J (2014) Kinetic evidence against partitioning of the ubiquinone pool and the catalytic relevance of respiratory-chain supercomplexes. Proc Natl Acad Sci U S A 111, 15735-40
2013
Chouchani ET, Methner C, Nadtochiy SM, Logan A, Pell VR, Ding S, James AM, Cochemé HM, Reinhold J, Lilley KS, Partridge L, Fearnley IM, Robinson AJ, Hartley RC, Smith RAJ, Krieg T, Brookes PS & Murphy MP (2013) Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I. Nat Med 19, 753-9
Birrell JA & Hirst J (2013) Investigation of NADH binding, hydride transfer, and NAD(+) dissociation during NADH oxidation by mitochondrial complex I using modified nicotinamide nucleotides. Biochemistry 52, 4048-55
Elrod JW & Molkentin JD (2013) Physiologic functions of cyclophilin D and the mitochondrial permeability transition pore. Circ J 77, 1111-22
Carroll J, Ding S, Fearnley IM & Walker JE (2013) Post-translational modifications near the quinone binding site of mammalian complex I. J Biol Chem 288, 24799-808
J Y Jones A & Hirst J (2013) A spectrophotometric coupled enzyme assay to measure the activity of succinate dehydrogenase. Anal Biochem 442, 19-23
2012
Hurd TR, Collins Y, Abakumova I, Chouchani ET, Baranowski B, Fearnley IM, Prime TA, Murphy MP & James AM (2012) Inactivation of pyruvate dehydrogenase kinase 2 by mitochondrial reactive oxygen species. J Biol Chem 287, 35153-60
Pung YFen, Rocic P, Murphy MP, Smith RAJ, Hafemeister J, Ohanyan V, Guarini G, Yin L & Chilian WM (2012) Resolution of mitochondrial oxidative stress rescues coronary collateral growth in Zucker obese fatty rats. Arterioscler Thromb Vasc Biol 32, 325-34
Rees DM, Montgomery MG, Leslie AGW & Walker JE (2012) Structural evidence of a new catalytic intermediate in the pathway of ATP hydrolysis by F1-ATPase from bovine heart mitochondria. Proc Natl Acad Sci U S A 109, 11139-43

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