Publications

Found 62 results
Filters: Keyword is Kinetics  [Clear All Filters]
2017
Springett R, King MS, Crichton PG & Kunji ERS (2017) Modelling the free energy profile of the mitochondrial ADP/ATP carrier. Biochim Biophys Acta 1858, 906-914
2016
King MS, Kerr M, Crichton PG, Springett R & Kunji ERS (2016) Formation of a cytoplasmic salt bridge network in the matrix state is a fundamental step in the transport mechanism of the mitochondrial ADP/ATP carrier. Biochim Biophys Acta 1857, 14-22
McCorvie TJ, Kopec J, Pey AL, Fitzpatrick F, Patel D, Chalk R, Shrestha L & Yue WW (2016) Molecular basis of classic galactosemia from the structure of human galactose 1-phosphate uridylyltransferase. Hum Mol Genet 25, 2234-2244
2014
Blaza JN, Serreli R, J Y Jones A, Mohammed K & Hirst J (2014) Kinetic evidence against partitioning of the ubiquinone pool and the catalytic relevance of respiratory-chain supercomplexes. Proc Natl Acad Sci U S A 111, 15735-40
Azarashvili T, Odinokova I, Bakunts A, Ternovsky V, Krestinina O, Tyynelä J & Saris N-ELeo (2014) Potential role of subunit c of F0F1-ATPase and subunit c of storage body in the mitochondrial permeability transition. Effect of the phosphorylation status of subunit c on pore opening. Cell Calcium 55, 69-77
2013
Birrell JA, Morina K, Bridges HR, Friedrich T & Hirst J (2013) Investigating the function of [2Fe-2S] cluster N1a, the off-pathway cluster in complex I, by manipulating its reduction potential. Biochem J 456, 139-46
Birrell JA & Hirst J (2013) Investigation of NADH binding, hydride transfer, and NAD(+) dissociation during NADH oxidation by mitochondrial complex I using modified nicotinamide nucleotides. Biochemistry 52, 4048-55
J Y Jones A & Hirst J (2013) A spectrophotometric coupled enzyme assay to measure the activity of succinate dehydrogenase. Anal Biochem 442, 19-23
2012
Divakaruni AS, Humphrey DM & Brand MD (2012) Fatty acids change the conformation of uncoupling protein 1 (UCP1). J Biol Chem 287, 36845-53
Kelso GF, Maroz A, Cochemé HM, Logan A, Prime TA, Peskin AV, Winterbourn CC, James AM, Ross MF, Brooker S, Porteous CM, Anderson RF, Murphy MP & Smith RAJ (2012) A mitochondria-targeted macrocyclic Mn(II) superoxide dismutase mimetic. Chem Biol 19, 1237-46
2011
Armstrong FA & Hirst J (2011) Reversibility and efficiency in electrocatalytic energy conversion and lessons from enzymes. Proc Natl Acad Sci U S A 108, 14049-54
2010
Crichton PG, Albury MS, Affourtit C & Moore AL (2010) Mutagenesis of the Sauromatum guttatum alternative oxidase reveals features important for oxygen binding and catalysis. Biochim Biophys Acta 1797, 732-7
Zhou A, Carrell RW, Murphy MP, Wei Z, Yan Y, Stanley PLD, Stein PE, Pipkin FBroughton & Read RJ (2010) A redox switch in angiotensinogen modulates angiotensin release. Nature 468, 108-11
2009
Affourtit C & Brand MD (2009) Measuring mitochondrial bioenergetics in INS-1E insulinoma cells. Methods Enzymol 457, 405-24
Birrell JA, Yakovlev G & Hirst J (2009) Reactions of the flavin mononucleotide in complex I: a combined mechanism describes NADH oxidation coupled to the reduction of APAD+, ferricyanide, or molecular oxygen. Biochemistry 48, 12005-13
King MS, Sharpley MS & Hirst J (2009) Reduction of hydrophilic ubiquinones by the flavin in mitochondrial NADH:ubiquinone oxidoreductase (Complex I) and production of reactive oxygen species. Biochemistry 48, 2053-62
Yagi H, Konno H, Murakami-Fuse T, Isu A, Oroguchi T, Akutsu H, Ikeguchi M & Hisabori T (2009) Structural and functional analysis of the intrinsic inhibitor subunit epsilon of F1-ATPase from photosynthetic organisms. Biochem J 425, 85-94
2008
Azzu V, Parker N & Brand MD (2008) High membrane potential promotes alkenal-induced mitochondrial uncoupling and influences adenine nucleotide translocase conformation. Biochem J 413, 323-32
Murata T, Yamato I, Kakinuma Y, Shirouzu M, Walker JE, Yokoyama S & Iwata S (2008) Ion binding and selectivity of the rotor ring of the Na+-transporting V-ATPase. Proc Natl Acad Sci U S A 105, 8607-12
Reda T, Plugge CM, Abram NJ & Hirst J (2008) Reversible interconversion of carbon dioxide and formate by an electroactive enzyme. Proc Natl Acad Sci U S A 105, 10654-8
2007
Kuhnle GGC, Story GW, Reda T, Mani AR, Moore KP, Lunn JC & Bingham SA (2007) Diet-induced endogenous formation of nitroso compounds in the GI tract. Free Radic Biol Med 43, 1040-7
Lunn JC, Kuhnle G, Mai V, Frankenfeld C, Shuker DEG, Glen RC, Goodman JM, Pollock JRA & Bingham SA (2007) The effect of haem in red and processed meat on the endogenous formation of N-nitroso compounds in the upper gastrointestinal tract. Carcinogenesis 28, 685-90
Lou P-H, Hansen BS, Olsen PH, Tullin S, Murphy MP & Brand MD (2007) Mitochondrial uncouplers with an extraordinary dynamic range. Biochem J 407, 129-40
Amo T & Brand MD (2007) Were inefficient mitochondrial haplogroups selected during migrations of modern humans? A test using modular kinetic analysis of coupling in mitochondria from cybrid cell lines. Biochem J 404, 345-51
Bamber L, Harding M, Monné M, Slotboom D-J & Kunji ERS (2007) The yeast mitochondrial ADP/ATP carrier functions as a monomer in mitochondrial membranes. Proc Natl Acad Sci U S A 104, 10830-4

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