Publications

Found 21 results
Filters: Keyword is Uncoupling Protein 2  [Clear All Filters]
2011
Divakaruni AS & Brand MD (2011) The regulation and physiology of mitochondrial proton leak. Physiology (Bethesda) 26, 192-205
Affourtit C, Jastroch M & Brand MD (2011) Uncoupling protein-2 attenuates glucose-stimulated insulin secretion in INS-1E insulinoma cells by lowering mitochondrial reactive oxygen species. Free Radic Biol Med 50, 609-16
2010
Azzu V & Brand MD (2010) Degradation of an intramitochondrial protein by the cytosolic proteasome. J Cell Sci 123, 578-85
Azzu V, Jastroch M, Divakaruni AS & Brand MD (2010) The regulation and turnover of mitochondrial uncoupling proteins. Biochim Biophys Acta 1797, 785-91
2009
Parker N, Vidal-Puig AJ, Azzu V & Brand MD (2009) Dysregulation of glucose homeostasis in nicotinamide nucleotide transhydrogenase knockout mice is independent of uncoupling protein 2. Biochim Biophys Acta 1787, 1451-7
Affourtit C & Brand MD (2009) Measuring mitochondrial bioenergetics in INS-1E insulinoma cells. Methods Enzymol 457, 405-24
2008
Azzu V, Affourtit C, Breen EP, Parker N & Brand MD (2008) Dynamic regulation of uncoupling protein 2 content in INS-1E insulinoma cells. Biochim Biophys Acta 1777, 1378-83
Affourtit C & Brand MD (2008) On the role of uncoupling protein-2 in pancreatic beta cells. Biochim Biophys Acta 1777, 973-9
Brookes PS, Parker N, Buckingham JA, Vidal-Puig A, Halestrap AP, Gunter TE, Nicholls DG, Bernardi P, Lemasters JJ & Brand MD (2008) UCPs--unlikely calcium porters. Nat Cell Biol 10, 1235-7; author reply 1237-40
Affourtit C & Brand MD (2008) Uncoupling protein-2 contributes significantly to high mitochondrial proton leak in INS-1E insulinoma cells and attenuates glucose-stimulated insulin secretion. Biochem J 409, 199-204
2005
Brand MD & Esteves TC (2005) Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3. Cell Metab 2, 85-93
Esteves TC & Brand MD (2005) The reactions catalysed by the mitochondrial uncoupling proteins UCP2 and UCP3. Biochim Biophys Acta 1709, 35-44
2004
Brand MD, Affourtit C, Esteves TC, Green K, Lambert AJ, Miwa S, Pakay JL & Parker N (2004) Mitochondrial superoxide: production, biological effects, and activation of uncoupling proteins. Free Radic Biol Med 37, 755-67
2003
Jekabsons MB, Echtay KS, Arechaga I & Brand MD (2003) Molecular properties of purified human uncoupling protein 2 refolded from bacterial inclusion bodies. J Bioenerg Biomembr 35, 409-18
2002
Jekabsons MB, Echtay KS & Brand MD (2002) Nucleotide binding to human uncoupling protein-2 refolded from bacterial inclusion bodies. Biochem J 366, 565-71
Echtay KS, Murphy MP, Smith RAJ, Talbot DA & Brand MD (2002) Superoxide activates mitochondrial uncoupling protein 2 from the matrix side. Studies using targeted antioxidants. J Biol Chem 277, 47129-35
Echtay KS, Roussel D, St-Pierre J, Jekabsons MB, Cadenas S, Stuart JA, Harper JA, Roebuck SJ, Morrison A, Pickering S, Clapham JC & Brand MD (2002) Superoxide activates mitochondrial uncoupling proteins. Nature 415, 96-9
2001
Echtay KS & Brand MD (2001) Coenzyme Q induces GDP-sensitive proton conductance in kidney mitochondria. Biochem Soc Trans 29, 763-8
Stuart JA, Cadenas S, Jekabsons MB, Roussel D & Brand MD (2001) Mitochondrial proton leak and the uncoupling protein 1 homologues. Biochim Biophys Acta 1504, 144-58
Stuart JA, Harper JA, Brindle KM, Jekabsons MB & Brand MD (2001) Physiological levels of mammalian uncoupling protein 2 do not uncouple yeast mitochondria. J Biol Chem 276, 18633-9