Publications

Found 77 results
Filters: Keyword is Binding Sites  [Clear All Filters]
2018
Agip A-NA, Blaza JN, Bridges HR, Viscomi C, Rawson S, Muench SP & Hirst J (2018) Cryo-EM structures of complex I from mouse heart mitochondria in two biochemically defined states. Nat Struct Mol Biol 25, 548-556
2016
Letts JA, Fiedorczuk K & Sazanov LA (2016) The architecture of respiratory supercomplexes. Nature 537, 644-648
Fiedorczuk K, Letts JA, Degliesposti G, Kaszuba K, Skehel M & Sazanov LA (2016) Atomic structure of the entire mammalian mitochondrial complex I. Nature 538, 406-410
McCorvie TJ, Kopec J, Pey AL, Fitzpatrick F, Patel D, Chalk R, Shrestha L & Yue WW (2016) Molecular basis of classic galactosemia from the structure of human galactose 1-phosphate uridylyltransferase. Hum Mol Genet 25, 2234-2244
Zhu J, Vinothkumar KR & Hirst J (2016) Structure of mammalian respiratory complex I. Nature 536, 354-8
2015
Shanmughapriya S, Rajan S, Hoffman NE, Higgins AM, Tomar D, Nemani N, Hines KJ, Smith DJ, Eguchi A, Vallem S, Shaikh F, Cheung M, Leonard NJ, Stolakis RS, Wolfers MP, Ibetti J, J Chuprun K, Jog NR, Houser SR, Koch WJ, Elrod JW & Madesh M (2015) SPG7 Is an Essential and Conserved Component of the Mitochondrial Permeability Transition Pore. Mol Cell 60, 47-62
Tworowski D, Klipcan L, Peretz M, Moor N & Safro MG (2015) Universal pathway for posttransfer editing reactions: insights from the crystal structure of TtPheRS with puromycin. Proc Natl Acad Sci U S A 112, 3967-72
2014
Srinivasan V, Pierik AJ & Lill R (2014) Crystal structures of nucleotide-free and glutathione-bound mitochondrial ABC transporter Atm1. Science 343, 1137-40
Heikal A, Nakatani Y, Dunn E, Weimar MR, Day CL, Baker EN, J Lott S, Sazanov LA & Cook GM (2014) Structure of the bacterial type II NADH dehydrogenase: a monotopic membrane protein with an essential role in energy generation. Mol Microbiol 91, 950-64
2013
Carroll J, Ding S, Fearnley IM & Walker JE (2013) Post-translational modifications near the quinone binding site of mammalian complex I. J Biol Chem 288, 24799-808
Robinson GC, Bason JV, Montgomery MG, Fearnley IM, Mueller DM, Leslie AGW & Walker JE (2013) The structure of F₁-ATPase from Saccharomyces cerevisiae inhibited by its regulatory protein IF₁. Open Biol 3, 120164
Shintre CA, Pike ACW, Li Q, Kim J-I, Barr AJ, Goubin S, Shrestha L, Yang J, Berridge G, Ross J, Stansfeld PJ, Sansom MSP, Edwards AM, Bountra C, Marsden BD, von Delft F, Bullock AN, Gileadi O, Burgess-Brown NA & Carpenter EP (2013) Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states. Proc Natl Acad Sci U S A 110, 9710-5
Monné M, Palmieri F & Kunji ERS (2013) The substrate specificity of mitochondrial carriers: mutagenesis revisited. Mol Membr Biol 30, 149-59
Mifsud J, Ravaud S, Krammer E-M, Chipot C, Kunji ERS, Pebay-Peyroula E & Dehez F (2013) The substrate specificity of the human ADP/ATP carrier AAC1. Mol Membr Biol 30, 160-8
2012
Rees DM, Montgomery MG, Leslie AGW & Walker JE (2012) Structural evidence of a new catalytic intermediate in the pathway of ATP hydrolysis by F1-ATPase from bovine heart mitochondria. Proc Natl Acad Sci U S A 109, 11139-43
Monné M, Miniero DValeria, Daddabbo L, Robinson AJ, Kunji ERS & Palmieri F (2012) Substrate specificity of the two mitochondrial ornithine carriers can be swapped by single mutation in substrate binding site. J Biol Chem 287, 7925-34
2011
Bason JV, Runswick MJ, Fearnley IM & Walker JE (2011) Binding of the inhibitor protein IF(1) to bovine F(1)-ATPase. J Mol Biol 406, 443-53
Murai M, Mashimo Y, Hirst J & Miyoshi H (2011) Exploring interactions between the 49 kDa and ND1 subunits in mitochondrial NADH-ubiquinone oxidoreductase (complex I) by photoaffinity labeling. Biochemistry 50, 6901-8
2010
Efremov RG, Baradaran R & Sazanov LA (2010) The architecture of respiratory complex I. Nature 465, 441-5
Kunji ERS & Robinson AJ (2010) Coupling of proton and substrate translocation in the transport cycle of mitochondrial carriers. Curr Opin Struct Biol 20, 440-7
2009
Yagi H, Konno H, Murakami-Fuse T, Isu A, Oroguchi T, Akutsu H, Ikeguchi M & Hisabori T (2009) Structural and functional analysis of the intrinsic inhibitor subunit epsilon of F1-ATPase from photosynthetic organisms. Biochem J 425, 85-94
Berrisford JM & Sazanov LA (2009) Structural basis for the mechanism of respiratory complex I. J Biol Chem 284, 29773-83
2008
Hurd TR, Requejo R, Filipovska A, Brown S, Prime TA, Robinson AJ, Fearnley IM & Murphy MP (2008) Complex I within oxidatively stressed bovine heart mitochondria is glutathionylated on Cys-531 and Cys-704 of the 75-kDa subunit: potential role of CYS residues in decreasing oxidative damage. J Biol Chem 283, 24801-15
Murata T, Yamato I, Kakinuma Y, Shirouzu M, Walker JE, Yokoyama S & Iwata S (2008) Ion binding and selectivity of the rotor ring of the Na+-transporting V-ATPase. Proc Natl Acad Sci U S A 105, 8607-12
Robinson AJ, Overy C & Kunji ERS (2008) The mechanism of transport by mitochondrial carriers based on analysis of symmetry. Proc Natl Acad Sci U S A 105, 17766-71

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