Publications

Found 22 results
Filters: Keyword is Glutathione  [Clear All Filters]
2015
Booty LM, King MS, Thangaratnarajah C, Majd H, James AM, Kunji ERS & Murphy MP (2015) The mitochondrial dicarboxylate and 2-oxoglutarate carriers do not transport glutathione. FEBS Lett 589, 621-8
2014
Srinivasan V, Pierik AJ & Lill R (2014) Crystal structures of nucleotide-free and glutathione-bound mitochondrial ABC transporter Atm1. Science 343, 1137-40
2012
von Montfort C, Matias N, Fernandez A, Fucho R, de la Rosa LConde, Martinez-Chantar MLuz, Mato JM, Machida K, Tsukamoto H, Murphy MP, Mansouri A, Kaplowitz N, Garcia-Ruiz C & Fernandez-Checa JC (2012) Mitochondrial GSH determines the toxic or therapeutic potential of superoxide scavenging in steatohepatitis. J Hepatol 57, 852-9
Murphy MP (2012) Mitochondrial thiols in antioxidant protection and redox signaling: distinct roles for glutathionylation and other thiol modifications. Antioxid Redox Signal 16, 476-95
2011
Vlachantoni D, Bramall AN, Murphy MP, Taylor RW, Shu X, Tulloch B, Van Veen T, Turnbull DM, McInnes RR & Wright AF (2011) Evidence of severe mitochondrial oxidative stress and a protective effect of low oxygen in mouse models of inherited photoreceptor degeneration. Hum Mol Genet 20, 322-35
Marthandan S, Murphy MP, Billett E & Barnett Y (2011) An investigation of the effects of MitoQ on human peripheral mononuclear cells. Free Radic Res 45, 351-8
McManus MJ, Murphy MP & Franklin JL (2011) The mitochondria-targeted antioxidant MitoQ prevents loss of spatial memory retention and early neuropathology in a transgenic mouse model of Alzheimer's disease. J Neurosci 31, 15703-15
2010
Requejo R, Hurd TR, Costa NJ & Murphy MP (2010) Cysteine residues exposed on protein surfaces are the dominant intramitochondrial thiol and may protect against oxidative damage. FEBS J 277, 1465-80
Requejo R, Chouchani ET, Hurd TR, Menger KE, Hampton MB & Murphy MP (2010) Measuring mitochondrial protein thiol redox state. Methods Enzymol 474, 123-47
2006
Iuso A, Scacco S, Piccoli C, Bellomo F, Petruzzella V, Trentadue R, Minuto M, Ripoli M, Capitanio N, Zeviani M & Papa S (2006) Dysfunctions of cellular oxidative metabolism in patients with mutations in the NDUFS1 and NDUFS4 genes of complex I. J Biol Chem 281, 10374-80
Filipovska A & Murphy MP (2006) Measurement of protein glutathionylation. Curr Protoc Toxicol Chapter 6, Unit6.11
Filipovska A & Murphy MP (2006) Overview of protein glutathionylation. Curr Protoc Toxicol Chapter 6, Unit6.10
Dahm CC, Moore K & Murphy MP (2006) Persistent S-nitrosation of complex I and other mitochondrial membrane proteins by S-nitrosothiols but not nitric oxide or peroxynitrite: implications for the interaction of nitric oxide with mitochondria. J Biol Chem 281, 10056-65
2005
Hurd TR, Filipovska A, Costa NJ, Dahm CC & Murphy MP (2005) Disulphide formation on mitochondrial protein thiols. Biochem Soc Trans 33, 1390-3
Hurd TR, Costa NJ, Dahm CC, Beer SM, Brown SE, Filipovska A & Murphy MP (2005) Glutathionylation of mitochondrial proteins. Antioxid Redox Signal 7, 999-1010
Bianchi P, Pimentel DR, Murphy MP, Colucci WS & Parini A (2005) A new hypertrophic mechanism of serotonin in cardiac myocytes: receptor-independent ROS generation. FASEB J 19, 641-3
Filipovska A, Kelso GF, Brown SE, Beer SM, Smith RAJ & Murphy MP (2005) Synthesis and characterization of a triphenylphosphonium-conjugated peroxidase mimetic. Insights into the interaction of ebselen with mitochondria. J Biol Chem 280, 24113-26
2003
Costa NJ, Dahm CC, Hurrell F, Taylor ER & Murphy MP (2003) Interactions of mitochondrial thiols with nitric oxide. Antioxid Redox Signal 5, 291-305
Taylor ER, Hurrell F, Shannon RJ, Lin T-K, Hirst J & Murphy MP (2003) Reversible glutathionylation of complex I increases mitochondrial superoxide formation. J Biol Chem 278, 19603-10