Publications

Found 52 results
Filters: Keyword is Mitochondria, Liver  [Clear All Filters]
2015
Teixeira J, Soares P, Benfeito S, Murphy MP, Oliveira PJ & Borges F (2015) Bridging the gap between nature and antioxidant setbacks: delivering caffeic acid to mitochondria. Methods Mol Biol 1265, 73-83
2014
Bridges HR, J Y Jones A, Pollak MN & Hirst J (2014) Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria. Biochem J 462, 475-87
Pun PBoon Li, Logan A, Darley-Usmar V, Chacko B, Johnson MS, Huang GW, Rogatti S, Prime TA, Methner C, Krieg T, Fearnley IM, Larsen L, Larsen DS, Menger KE, Collins Y, James AM, Kumar GDKishore, Hartley RC, Smith RAJ & Murphy MP (2014) A mitochondria-targeted mass spectrometry probe to detect glyoxals: implications for diabetes. Free Radic Biol Med 67, 437-50
Sood A, Jeyaraju DVijey, Prudent J, Caron A, Lemieux P, McBride HMay, Laplante M, Tóth K & Pellegrini L (2014) A Mitofusin-2-dependent inactivating cleavage of Opa1 links changes in mitochondria cristae and ER contacts in the postprandial liver. Proc Natl Acad Sci U S A 111, 16017-22
Azarashvili T, Odinokova I, Bakunts A, Ternovsky V, Krestinina O, Tyynelä J & Saris N-ELeo (2014) Potential role of subunit c of F0F1-ATPase and subunit c of storage body in the mitochondrial permeability transition. Effect of the phosphorylation status of subunit c on pore opening. Cell Calcium 55, 69-77
2013
Giorgio V, von Stockum S, Antoniel M, Fabbro A, Fogolari F, Forte M, Glick GD, Petronilli V, Zoratti M, Szabó I, Lippe G & Bernardi P (2013) Dimers of mitochondrial ATP synthase form the permeability transition pore. Proc Natl Acad Sci U S A 110, 5887-92
Finichiu PG, James AM, Larsen L, Smith RAJ & Murphy MP (2013) Mitochondrial accumulation of a lipophilic cation conjugated to an ionisable group depends on membrane potential, pH gradient and pK(a): implications for the design of mitochondrial probes and therapies. J Bioenerg Biomembr 45, 165-73
2012
von Montfort C, Matias N, Fernandez A, Fucho R, de la Rosa LConde, Martinez-Chantar MLuz, Mato JM, Machida K, Tsukamoto H, Murphy MP, Mansouri A, Kaplowitz N, Garcia-Ruiz C & Fernandez-Checa JC (2012) Mitochondrial GSH determines the toxic or therapeutic potential of superoxide scavenging in steatohepatitis. J Hepatol 57, 852-9
2011
Chacko BK, Srivastava A, Johnson MS, Benavides GA, Chang MJung, Ye Y, Jhala N, Murphy MP, Kalyanaraman B & Darley-Usmar VM (2011) Mitochondria-targeted ubiquinone (MitoQ) decreases ethanol-dependent micro and macro hepatosteatosis. Hepatology 54, 153-63
2010
Requejo R, Hurd TR, Costa NJ & Murphy MP (2010) Cysteine residues exposed on protein surfaces are the dominant intramitochondrial thiol and may protect against oxidative damage. FEBS J 277, 1465-80
Gane EJ, Weilert F, Orr DW, Keogh GF, Gibson M, Lockhart MM, Frampton CM, Taylor KM, Smith RAJ & Murphy MP (2010) The mitochondria-targeted anti-oxidant mitoquinone decreases liver damage in a phase II study of hepatitis C patients. Liver Int 30, 1019-26
Requejo R, Chouchani ET, James AM, Prime TA, Lilley KS, Fearnley IM & Murphy MP (2010) Quantification and identification of mitochondrial proteins containing vicinal dithiols. Arch Biochem Biophys 504, 228-35
2009
Reyes A, Yasukawa T, Cluett TJ & Holt IJ (2009) Analysis of mitochondrial DNA by two-dimensional agarose gel electrophoresis. Methods Mol Biol 554, 15-35
Trnka J, Blaikie FH, Logan A, Smith RAJ & Murphy MP (2009) Antioxidant properties of MitoTEMPOL and its hydroxylamine. Free Radic Res 43, 4-12
Singh A, Wirtz M, Parker N, Hogan M, Strahler J, Michailidis G, Schmidt S, Vidal-Puig A, Diano S, Andrews P, Brand MD & Friedman J (2009) Leptin-mediated changes in hepatic mitochondrial metabolism, structure, and protein levels. Proc Natl Acad Sci U S A 106, 13100-5
King MS, Sharpley MS & Hirst J (2009) Reduction of hydrophilic ubiquinones by the flavin in mitochondrial NADH:ubiquinone oxidoreductase (Complex I) and production of reactive oxygen species. Biochemistry 48, 2053-62
2008
Cochemé HM & Murphy MP (2008) Complex I is the major site of mitochondrial superoxide production by paraquat. J Biol Chem 283, 1786-98
Azzu V, Parker N & Brand MD (2008) High membrane potential promotes alkenal-induced mitochondrial uncoupling and influences adenine nucleotide translocase conformation. Biochem J 413, 323-32
Ross MF, Prime TA, Abakumova I, James AM, Porteous CM, Smith RAJ & Murphy MP (2008) Rapid and extensive uptake and activation of hydrophobic triphenylphosphonium cations within cells. Biochem J 411, 633-45
Brookes PS, Parker N, Buckingham JA, Vidal-Puig A, Halestrap AP, Gunter TE, Nicholls DG, Bernardi P, Lemasters JJ & Brand MD (2008) UCPs--unlikely calcium porters. Nat Cell Biol 10, 1235-7; author reply 1237-40
2007
He J, Mao C-C, Reyes A, Sembongi H, Di Re M, Granycome C, Clippingdale AB, Fearnley IM, Harbour M, Robinson AJ, Reichelt S, Spelbrink JN, Walker JE & Holt IJ (2007) The AAA+ protein ATAD3 has displacement loop binding properties and is involved in mitochondrial nucleoid organization. J Cell Biol 176, 141-6
Jastroch M, Buckingham JA, Helwig M, Klingenspor M & Brand MD (2007) Functional characterisation of UCP1 in the common carp: uncoupling activity in liver mitochondria and cold-induced expression in the brain. J Comp Physiol B 177, 743-52
Brown SE, Ross MF, Sanjuan-Pla A, Manas A-RB, Smith RAJ & Murphy MP (2007) Targeting lipoic acid to mitochondria: synthesis and characterization of a triphenylphosphonium-conjugated alpha-lipoyl derivative. Free Radic Biol Med 42, 1766-80
Baines CP, Kaiser RA, Sheiko T, Craigen WJ & Molkentin JD (2007) Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death. Nat Cell Biol 9, 550-5
2006
Ross MF, Da Ros T, Blaikie FH, Prime TA, Porteous CM, Severina II, Skulachev VP, Kjaergaard HG, Smith RAJ & Murphy MP (2006) Accumulation of lipophilic dications by mitochondria and cells. Biochem J 400, 199-208

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