Publications

Found 1895 results
2019
Ruprecht JJ, King MS, Zögg T, Aleksandrova AA, Pardon E, Crichton PG, Steyaert J & Kunji ERS (2019) The Molecular Mechanism of Transport by the Mitochondrial ADP/ATP Carrier. Cell 176, 435-447.e15
Ugun-Klusek A, Theodosi TS, Fitzgerald JC, Burté F, Ufer C, Boocock DJ, Yu-Wai-Man P, Bedford L & E Billett E (2019) Monoamine oxidase-A promotes protective autophagy in human SH-SY5Y neuroblastoma cells through Bcl-2 phosphorylation. Redox Biol 20, 167-181
Saoura M, Powell CA, Kopajtich R, Alahmad A, Al-Balool HH, Albash B, Alfadhel M, Alston CL, Bertini E, Bonnen PE, Bratkovic D, Carrozzo R, Donati MA, Di Nottia M, Ghezzi D, Goldstein A, Haan E, Horvath R, Hughes J, Invernizzi F, Lamantea E, Lucas B, Pinnock K-G, Pujantell M, Rahman S, Rebelo-Guiomar P, Santra S, Verrigni D, McFarland R, Prokisch H, Taylor RW, Levinger L & Minczuk M (2019) Mutations in ELAC2 associated with hypertrophic cardiomyopathy impair mitochondrial tRNA 3'-end processing. Hum Mutat
van der Lee SJ, Conway OJ, Jansen I, Carrasquillo MM, Kleineidam L, van den Akker E, Hernández I, van Eijk KR, Stringa N, Chen JA, Zettergren A, Andlauer TFM, Diez-Fairen M, Simon-Sanchez J, Lleó A, Zetterberg H, Nygaard M, Blauwendraat C, Savage JE, Mengel-From J, Moreno-Grau S, Wagner M, Fortea J, Keogh MJ, Blennow K, Skoog I, Friese MA, Pletnikova O, Zulaica M, Lage C, de Rojas I, Riedel-Heller S, Illán-Gala I, Wei W, Jeune B, Orellana A, Bergh FThen, Wang X, Hulsman M, Beker N, Tesi N, Morris CM, Indakoetxea B, Collij LE, Scherer M, Morenas-Rodríguez E, Ironside JW, van Berckel BNM, Alcolea D, Wiendl H, Strickland SL, Pastor P, Rodríguez ERodríguez, Boeve BF, Petersen RC, Ferman TJ, van Gerpen JA, Reinders MJT, Uitti RJ, Tárraga L, Maier W, Dols-Icardo O, Kawalia A, Dalmasso MCarolina, Boada M, Zettl UK, van Schoor NM, Beekman M, Allen M, Masliah E, de Munain ALópez, Pantelyat A, Wszolek ZK, Ross OA, Dickson DW, Graff-Radford NR, Knopman D, Rademakers R, Lemstra AW, Pijnenburg YAL, Scheltens P, Gasser T, Chinnery PF, Hemmer B, Huisman MA, Troncoso J, Moreno F, Nohr EA, Sørensen TIA, Heutink P, Sánchez-Juan P, Posthuma D, Clarimón J, Christensen K, Ertekin-Taner N, Scholz SW, Ramirez A, Ruiz A, Slagboom E, van der Flier WM & Holstege H (2019) A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity. Acta Neuropathol
Lim PJin, Duarte TL, Arezes J, Garcia-Santos D, Hamdi A, Pasricha S-R, Armitage AE, Mehta H, Wideman S, Santos AG, Santos-Gonçalves A, Morovat A, Hughes JR, Soilleux E, Wang C-Y, Bayer AL, Klenerman P, Willberg CB, Hartley RC, Murphy MP, Babitt JL, Ponka P, Porto G & Drakesmith H (2019) Nrf2 controls iron homeostasis in haemochromatosis and thalassaemia via Bmp6 and hepcidin. Nat Metab 1, 519-531
Ng YShiau, Martikainen MH, Gorman GS, Blain A, Bugiardini E, Bunting A, Schaefer AM, Alston CL, Blakely EL, Sharma S, Hughes I, Lim A, de Goede C, McEntagart M, Spinty S, Horrocks I, Roberts M, Woodward CE, Chinnery PF, Horvath R, Nesbitt V, Fratter C, Poulton J, Hanna MG, Pitceathly RDS, Taylor RW, Turnbull DM & McFarland R (2019) Pathogenic variants in MT-ATP6: A United Kingdom-based mitochondrial disease cohort study. Ann Neurol
Carroll J, He J, Ding S, Fearnley IM & Walker JE (2019) Persistence of the permeability transition pore in human mitochondria devoid of an assembled ATP synthase. Proc Natl Acad Sci U S A 116, 12816-12821
Posse V, Al-Behadili A, Uhler JP, Clausen AR, Reyes A, Zeviani M, Falkenberg M & Gustafsson CM (2019) RNase H1 directs origin-specific initiation of DNA replication in human mitochondria. PLoS Genet 15, e1007781
Booty LM, Gawel JM, Cvetko F, Caldwell ST, Hall AR, Mulvey JF, James AM, Hinchy EC, Prime TA, Arndt S, Benincá C, Bright TP, Clatworthy MR, Ferdinand JR, Prag HA, Logan A, Prudent J, Krieg T, Hartley RC & Murphy MP (2019) Selective Disruption of Mitochondrial Thiol Redox State in Cells and In Vivo. Cell Chem Biol 26, 449-461.e8
Ruprecht JJ & Kunji ERs (2019) Structural changes in the transport cycle of the mitochondrial ADP/ATP carrier. Curr Opin Struct Biol 57, 135-144
Park J, Lee S-Y, Jeong H, Kang M-G, Van Haute L, Minczuk M, Seo JKon, Jun Y, Myung K, Rhee H-W & Lee C (2019) The structure of human EXD2 reveals a chimeric 3' to 5' exonuclease domain that discriminates substrates via metal coordination. Nucleic Acids Res
Zhang ATianbu, Montgomery MG, Leslie AGW, Cook GM & Walker JE (2019) The structure of the catalytic domain of the ATP synthase from is a target for developing antitubercular drugs. Proc Natl Acad Sci U S A
Kim Y-R, Baek J-I, Kim SHwan, Kim M-A, Lee B, Ryu N, Kim K-H, Choi D-G, Kim H-M, Murphy MP, Macpherson G, Choo Y-S, Bok J, Lee K-Y, Park J-W & Kim U-K (2019) Therapeutic potential of the mitochondria-targeted antioxidant MitoQ in mitochondrial-ROS induced sensorineural hearing loss caused by Idh2 deficiency. Redox Biol 20, 544-555
Jurkute N, Harvey J & Yu-Wai-Man P (2019) Treatment strategies for Leber hereditary optic neuropathy. Curr Opin Neurol 32, 99-104
Tavoulari S, Thangaratnarajah C, Mavridou V, Harbour ME, Martinou J-C & Kunji ERs (2019) The yeast mitochondrial pyruvate carrier is a hetero-dimer in its functional state. EMBO J 38
2018
Mills EL, Pierce KA, Jedrychowski MP, Garrity R, Winther S, Vidoni S, Yoneshiro T, Spinelli JB, Lu GZ, Kazak L, Banks AS, Haigis MC, Kajimura S, Murphy MP, Gygi SP, Clish CB & Chouchani ET (2018) Accumulation of succinate controls activation of adipose tissue thermogenesis. Nature 560, 102-106
Ferguson DCJ, Smerdon GR, Harries LW, Dodd NJF, Murphy MP, Curnow A & Winyard PG (2018) Altered cellular redox homeostasis and redox responses under standard oxygen cell culture conditions versus physioxia. Free Radic Biol Med 126, 322-333
Signes A & Fernandez-Vizarra E (2018) Assembly of mammalian oxidative phosphorylation complexes I-V and supercomplexes. Essays Biochem 62, 255-270
He J, Ford HC, Carroll J, Douglas C, Gonzales E, Ding S, Fearnley IM & Walker JE (2018) Assembly of the membrane domain of ATP synthase in human mitochondria. Proc Natl Acad Sci U S A
Montgomery MG, Gahura O, Leslie AGW, Zíková A & Walker JE (2018) ATP synthase fromhas an elaborated canonical F-domain and conventional catalytic sites. Proc Natl Acad Sci U S A 115, 2102-2107
Kim M, Stepanova A, Niatsetskaya Z, Sosunov S, Arndt S, Murphy MP, Galkin A & Ten VS (2018) Attenuation of oxidative damage by targeting mitochondrial complex I in neonatal hypoxic-ischemic brain injury. Free Radic Biol Med 124, 517-524
Lee JJ, Sanchez-Martinez A, Zarate AMartinez, Benincá C, Mayor U, Clague MJ & Whitworth AJ (2018) Basal mitophagy is widespread inbut minimally affected by loss of Pink1 or parkin. J Cell Biol
Harborne SPD & Kunji ERS (2018) Calcium-regulated mitochondrial ATP-Mg/P carriers evolved from a fusion of an EF-hand regulatory domain with a mitochondrial ADP/ATP carrier-like domain. IUBMB Life 70, 1222-1232
Duncan AL, Ruprecht JJ, Kunji ERS & Robinson AJ (2018) Cardiolipin dynamics and binding to conserved residues in the mitochondrial ADP/ATP carrier. Biochim Biophys Acta 1860, 1035-1045
Keogh MJ, Steele HE & Chinnery PF (2018) Cardiovascular Genetics and GenomicsMitochondrial Cardiovascular Diseases (Kumar D, and Elliott Peds.), Springer International Publishing, Cham

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