Found 123 results
Filters: Keyword is Electron Transport Complex I  [Clear All Filters]
Birrell JA & Hirst J (2013) Investigation of NADH binding, hydride transfer, and NAD(+) dissociation during NADH oxidation by mitochondrial complex I using modified nicotinamide nucleotides. Biochemistry 52, 4048-55
Sazanov LA, Baradaran R, Efremov RG, Berrisford JM & Minhas G (2013) A long road towards the structure of respiratory complex I, a giant molecular proton pump. Biochem Soc Trans 41, 1265-71
Hirst J (2013) Mitochondrial complex I. Annu Rev Biochem 82, 551-75
Carroll J, Ding S, Fearnley IM & Walker JE (2013) Post-translational modifications near the quinone binding site of mammalian complex I. J Biol Chem 288, 24799-808
Ghezzi D & Zeviani M (2012) Assembly factors of human mitochondrial respiratory chain complexes: physiology and pathophysiology. Adv Exp Med Biol 748, 65-106
Efremov RG & Sazanov LA (2012) The coupling mechanism of respiratory complex I - a structural and evolutionary perspective. Biochim Biophys Acta 1817, 1785-95
Roberts PG & Hirst J (2012) The deactive form of respiratory complex I from mammalian mitochondria is a Na+/H+ antiporter. J Biol Chem 287, 34743-51
Haack TB, Haberberger B, Frisch E-M, Wieland T, Iuso A, Gorza M, Strecker V, Graf E, Mayr JA, Herberg U, Hennermann JB, Klopstock T, Kuhn KA, Ahting U, Sperl W, Wilichowski E, Hoffmann GF, Tesarova M, Hansikova H, Zeman J, Plecko B, Zeviani M, Wittig I, Strom TM, Schuelke M, Freisinger P, Meitinger T & Prokisch H (2012) Molecular diagnosis in mitochondrial complex I deficiency using exome sequencing. J Med Genet 49, 277-83
Bridges HR, Bill E & Hirst J (2012) Mössbauer spectroscopy on respiratory complex I: the iron-sulfur cluster ensemble in the NADH-reduced enzyme is partially oxidized. Biochemistry 51, 149-58
Haack TB, Madignier F, Herzer M, Lamantea E, Danhauser K, Invernizzi F, Koch J, Freitag M, Drost R, Hillier I, Haberberger B, Mayr JA, Ahting U, Tiranti V, Rötig A, Iuso A, Horvath R, Tesarova M, Baric I, Uziel G, Rolinski B, Sperl W, Meitinger T, Zeviani M, Freisinger P & Prokisch H (2012) Mutation screening of 75 candidate genes in 152 complex I deficiency cases identifies pathogenic variants in 16 genes including NDUFB9. J Med Genet 49, 83-9
Vlachantoni D, Bramall AN, Murphy MP, Taylor RW, Shu X, Tulloch B, Van Veen T, Turnbull DM, McInnes RR & Wright AF (2011) Evidence of severe mitochondrial oxidative stress and a protective effect of low oxygen in mouse models of inherited photoreceptor degeneration. Hum Mol Genet 20, 322-35
Yip C-ying, Harbour ME, Jayawardena K, Fearnley IM & Sazanov LA (2011) Evolution of respiratory complex I: "supernumerary" subunits are present in the alpha-proteobacterial enzyme. J Biol Chem 286, 5023-33
Murai M, Mashimo Y, Hirst J & Miyoshi H (2011) Exploring interactions between the 49 kDa and ND1 subunits in mitochondrial NADH-ubiquinone oxidoreductase (complex I) by photoaffinity labeling. Biochemistry 50, 6901-8
Davies KM, Strauss M, Daum B, Kief JH, Osiewacz HD, Rycovska A, Zickermann V & Kühlbrandt W (2011) Macromolecular organization of ATP synthase and complex I in whole mitochondria. Proc Natl Acad Sci U S A 108, 14121-6
Lee S, Tak E, Lee J, Rashid MA, Murphy MP, Ha J & Kim SSoo (2011) Mitochondrial H2O2 generated from electron transport chain complex I stimulates muscle differentiation. Cell Res 21, 817-34
Bridges HR, Birrell JA & Hirst J (2011) The mitochondrial-encoded subunits of respiratory complex I (NADH:ubiquinone oxidoreductase): identifying residues important in mechanism and disease. Biochem Soc Trans 39, 799-806
Efremov RG & Sazanov LA (2011) Respiratory complex I: 'steam engine' of the cell?. Curr Opin Struct Biol 21, 532-40
Efremov RG & Sazanov LA (2011) Structure of the membrane domain of respiratory complex I. Nature 476, 414-20
Pryde KR & Hirst J (2011) Superoxide is produced by the reduced flavin in mitochondrial complex I: a single, unified mechanism that applies during both forward and reverse electron transfer. J Biol Chem 286, 18056-65
Birrell JA, King MS & Hirst J (2011) A ternary mechanism for NADH oxidation by positively charged electron acceptors, catalyzed at the flavin site in respiratory complex I. FEBS Lett 585, 2318-22
Hirst J (2011) Why does mitochondrial complex I have so many subunits?. Biochem J 437, e1-3
Efremov RG, Baradaran R & Sazanov LA (2010) The architecture of respiratory complex I. Nature 465, 441-5
Roessler MM, King MS, Robinson AJ, Armstrong FA, Harmer J & Hirst J (2010) Direct assignment of EPR spectra to structurally defined iron-sulfur clusters in complex I by double electron-electron resonance. Proc Natl Acad Sci U S A 107, 1930-5
Haack TB, Danhauser K, Haberberger B, Hoser J, Strecker V, Boehm D, Uziel G, Lamantea E, Invernizzi F, Poulton J, Rolinski B, Iuso A, Biskup S, Schmidt T, Mewes H-W, Wittig I, Meitinger T, Zeviani M & Prokisch H (2010) Exome sequencing identifies ACAD9 mutations as a cause of complex I deficiency. Nat Genet 42, 1131-4
Lambert AJ, Buckingham JA, Boysen HM & Brand MD (2010) Low complex I content explains the low hydrogen peroxide production rate of heart mitochondria from the long-lived pigeon, Columba livia. Aging Cell 9, 78-91