Publications

Found 99 results
Filters: Keyword is Antioxidants  [Clear All Filters]
2009
Supinski GS, Murphy MP & Callahan LA (2009) MitoQ administration prevents endotoxin-induced cardiac dysfunction. Am J Physiol Regul Integr Comp Physiol 297, R1095-102
Maroz A, Anderson RF, Smith RAJ & Murphy MP (2009) Reactivity of ubiquinone and ubiquinol with superoxide and the hydroperoxyl radical: implications for in vivo antioxidant activity. Free Radic Biol Med 46, 105-9
2008
Tzounis X, Vulevic J, Kuhnle GGC, George T, Leonczak J, Gibson GR, Kwik-Uribe C & Spencer JPE (2008) Flavanol monomer-induced changes to the human faecal microflora. Br J Nutr 99, 782-92
Lowes DA, Thottakam BMV, Webster NR, Murphy MP & Galley HF (2008) The mitochondria-targeted antioxidant MitoQ protects against organ damage in a lipopolysaccharide-peptidoglycan model of sepsis. Free Radic Biol Med 45, 1559-65
Smith RAJ, Adlam VJ, Blaikie FH, Manas A-RB, Porteous CM, James AM, Ross MF, Logan A, Cochemé HM, Trnka J, Prime TA, Abakumova I, Jones BA, Filipovska A & Murphy MP (2008) Mitochondria-targeted antioxidants in the treatment of disease. Ann N Y Acad Sci 1147, 105-11
Trnka J, Blaikie FH, Smith RAJ & Murphy MP (2008) A mitochondria-targeted nitroxide is reduced to its hydroxylamine by ubiquinol in mitochondria. Free Radic Biol Med 44, 1406-19
Hobbs CE, Murphy MP, Smith RAJ & Oorschot DE (2008) Neonatal rat hypoxia-ischemia: Effect of the anti-oxidant mitoquinol, and S-PBN. Pediatr Int 50, 481-8
Myint PK, Luben RN, Welch AA, Bingham SA, Wareham NJ & Khaw K-T (2008) Plasma vitamin C concentrations predict risk of incident stroke over 10 y in 20 649 participants of the European Prospective Investigation into Cancer Norfolk prospective population study. Am J Clin Nutr 87, 64-9
Parker N, Vidal-Puig A & Brand MD (2008) Stimulation of mitochondrial proton conductance by hydroxynonenal requires a high membrane potential. Biosci Rep 28, 83-8
Murphy MP (2008) Targeting lipophilic cations to mitochondria. Biochim Biophys Acta 1777, 1028-31
2007
Vergani L, Malena A, Sabatelli P, Loro E, Cavallini L, Magalhaes P, Valente L, Bragantini F, Carrara F, Leger B, Poulton J, Russell AP & Holt IJ (2007) Cultured muscle cells display defects of mitochondrial myopathy ameliorated by anti-oxidants. Brain 130, 2715-24
James AM, Sharpley MS, Manas A-RB, Frerman FE, Hirst J, Smith RAJ & Murphy MP (2007) Interaction of the mitochondria-targeted antioxidant MitoQ with phospholipid bilayers and ubiquinone oxidoreductases. J Biol Chem 282, 14708-18
Jarvis RM, Göttert J, Murphy MP & Ledgerwood EC (2007) Mitochondria-targeted antioxidants do not prevent tumour necrosis factor-induced necrosis of L929 cells. Free Radic Res 41, 1041-6
Murphy MP & Smith RAJ (2007) Targeting antioxidants to mitochondria by conjugation to lipophilic cations. Annu Rev Pharmacol Toxicol 47, 629-56
Brown SE, Ross MF, Sanjuan-Pla A, Manas A-RB, Smith RAJ & Murphy MP (2007) Targeting lipoic acid to mitochondria: synthesis and characterization of a triphenylphosphonium-conjugated alpha-lipoyl derivative. Free Radic Biol Med 42, 1766-80
2006
Patel BD, Welch AA, Bingham SA, Luben RN, Day NE, Khaw K-T, Lomas DA & Wareham NJ (2006) Dietary antioxidants and asthma in adults. Thorax 61, 388-93
Iuso A, Scacco S, Piccoli C, Bellomo F, Petruzzella V, Trentadue R, Minuto M, Ripoli M, Capitanio N, Zeviani M & Papa S (2006) Dysfunctions of cellular oxidative metabolism in patients with mutations in the NDUFS1 and NDUFS4 genes of complex I. J Biol Chem 281, 10374-80
Covey MV, Murphy MP, Hobbs CE, Smith RAJ & Oorschot DE (2006) Effect of the mitochondrial antioxidant, Mito Vitamin E, on hypoxic-ischemic striatal injury in neonatal rats: a dose-response and stereological study. Exp Neurol 199, 513-9
Magwere T, West M, Riyahi K, Murphy MP, Smith RAJ & Partridge L (2006) The effects of exogenous antioxidants on lifespan and oxidative stress resistance in Drosophila melanogaster. Mech Ageing Dev 127, 356-70
M Camello-Almaraz C, Pozo MJ, Murphy MP & Camello PJ (2006) Mitochondrial production of oxidants is necessary for physiological calcium oscillations. J Cell Physiol 206, 487-94
2005
Pattison DJ, Symmons DPM, Lunt M, Welch A, Bingham SA, Day NE & Silman AJ (2005) Dietary beta-cryptoxanthin and inflammatory polyarthritis: results from a population-based prospective study. Am J Clin Nutr 82, 451-5
Hurd TR, Costa NJ, Dahm CC, Beer SM, Brown SE, Filipovska A & Murphy MP (2005) Glutathionylation of mitochondrial proteins. Antioxid Redox Signal 7, 999-1010
James AM, Cochemé HM, Smith RAJ & Murphy MP (2005) Interactions of mitochondria-targeted and untargeted ubiquinones with the mitochondrial respiratory chain and reactive oxygen species. Implications for the use of exogenous ubiquinones as therapies and experimental tools. J Biol Chem 280, 21295-312
Jenab M, Bingham S, Ferrari P, Friesen MD, Al-Delaimy WK, Luben R, Wareham N, Khaw K-T & Riboli E (2005) Long-term cryoconservation and stability of vitamin C in serum samples of the European prospective investigation into cancer and nutrition. Cancer Epidemiol Biomarkers Prev 14, 1837-40
Hughes G, Murphy MP & Ledgerwood EC (2005) Mitochondrial reactive oxygen species regulate the temporal activation of nuclear factor kappaB to modulate tumour necrosis factor-induced apoptosis: evidence from mitochondria-targeted antioxidants. Biochem J 389, 83-9

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