Publications

Found 81 results
Filters: Keyword is Ubiquinone  [Clear All Filters]
2009
Supinski GS, Murphy MP & Callahan LA (2009) MitoQ administration prevents endotoxin-induced cardiac dysfunction. Am J Physiol Regul Integr Comp Physiol 297, R1095-102
Maroz A, Anderson RF, Smith RAJ & Murphy MP (2009) Reactivity of ubiquinone and ubiquinol with superoxide and the hydroperoxyl radical: implications for in vivo antioxidant activity. Free Radic Biol Med 46, 105-9
King MS, Sharpley MS & Hirst J (2009) Reduction of hydrophilic ubiquinones by the flavin in mitochondrial NADH:ubiquinone oxidoreductase (Complex I) and production of reactive oxygen species. Biochemistry 48, 2053-62
2008
Lowes DA, Thottakam BMV, Webster NR, Murphy MP & Galley HF (2008) The mitochondria-targeted antioxidant MitoQ protects against organ damage in a lipopolysaccharide-peptidoglycan model of sepsis. Free Radic Biol Med 45, 1559-65
Trnka J, Blaikie FH, Smith RAJ & Murphy MP (2008) A mitochondria-targeted nitroxide is reduced to its hydroxylamine by ubiquinol in mitochondria. Free Radic Biol Med 44, 1406-19
Hobbs CE, Murphy MP, Smith RAJ & Oorschot DE (2008) Neonatal rat hypoxia-ischemia: Effect of the anti-oxidant mitoquinol, and S-PBN. Pediatr Int 50, 481-8
2007
James AM, Sharpley MS, Manas A-RB, Frerman FE, Hirst J, Smith RAJ & Murphy MP (2007) Interaction of the mitochondria-targeted antioxidant MitoQ with phospholipid bilayers and ubiquinone oxidoreductases. J Biol Chem 282, 14708-18
Zeviani M & Carelli V (2007) Mitochondrial disorders. Curr Opin Neurol 20, 564-71
Cochemé HM, Kelso GF, James AM, Ross MF, Trnka J, Mahendiran T, Asin-Cayuela J, Blaikie FH, Manas A-RB, Porteous CM, Adlam VJ, Smith RAJ & Murphy MP (2007) Mitochondrial targeting of quinones: therapeutic implications. Mitochondrion 7 Suppl, S94-102
2006
Marshall D, Fisher N, Grigic L, Zickermann V, Brandt U, Shannon RJ, Hirst J, Lawrence R & Rich PR (2006) ATR-FTIR redox difference spectroscopy of Yarrowia lipolytica and bovine complex I. Biochemistry 45, 5458-67
Magwere T, West M, Riyahi K, Murphy MP, Smith RAJ & Partridge L (2006) The effects of exogenous antioxidants on lifespan and oxidative stress resistance in Drosophila melanogaster. Mech Ageing Dev 127, 356-70
Sharpley MS, Shannon RJ, Draghi F & Hirst J (2006) Interactions between phospholipids and NADH:ubiquinone oxidoreductase (complex I) from bovine mitochondria. Biochemistry 45, 241-8
Sherwood S & Hirst J (2006) Investigation of the mechanism of proton translocation by NADH:ubiquinone oxidoreductase (complex I) from bovine heart mitochondria: does the enzyme operate by a Q-cycle mechanism?. Biochem J 400, 541-50
2004
James AM, Smith RAJ & Murphy MP (2004) Antioxidant and prooxidant properties of mitochondrial Coenzyme Q. Arch Biochem Biophys 423, 47-56
Asin-Cayuela J, Manas A-RB, James AM, Smith RAJ & Murphy MP (2004) Fine-tuning the hydrophobicity of a mitochondria-targeted antioxidant. FEBS Lett 571, 9-16
Murphy MP (2004) Investigating mitochondrial radical production using targeted probes. Biochem Soc Trans 32, 1011-4
Smith RAJ, Kelso GF, James AM & Murphy MP (2004) Targeting coenzyme Q derivatives to mitochondria. Methods Enzymol 382, 45-67
Esteves TC, Echtay KS, Jonassen T, Clarke CF & Brand MD (2004) Ubiquinone is not required for proton conductance by uncoupling protein 1 in yeast mitochondria. Biochem J 379, 309-15
2003
Zeviani M & Carelli V (2003) Mitochondrial disorders. Curr Opin Neurol 16, 585-94
Jauslin ML, Meier T, Smith RAJ & Murphy MP (2003) Mitochondria-targeted antioxidants protect Friedreich Ataxia fibroblasts from endogenous oxidative stress more effectively than untargeted antioxidants. FASEB J 17, 1972-4
Saretzki G, Murphy MP & von Zglinicki T (2003) MitoQ counteracts telomere shortening and elongates lifespan of fibroblasts under mild oxidative stress. Aging Cell 2, 141-3

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