Found 112 results
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Singh A, Wirtz M, Parker N, Hogan M, Strahler J, Michailidis G, Schmidt S, Vidal-Puig A, Diano S, Andrews P, Brand MD & Friedman J (2009) Leptin-mediated changes in hepatic mitochondrial metabolism, structure, and protein levels. Proc Natl Acad Sci U S A 106, 13100-5
Birrell JA, Yakovlev G & Hirst J (2009) Reactions of the flavin mononucleotide in complex I: a combined mechanism describes NADH oxidation coupled to the reduction of APAD+, ferricyanide, or molecular oxygen. Biochemistry 48, 12005-13
King MS, Sharpley MS & Hirst J (2009) Reduction of hydrophilic ubiquinones by the flavin in mitochondrial NADH:ubiquinone oxidoreductase (Complex I) and production of reactive oxygen species. Biochemistry 48, 2053-62
Berrisford JM & Sazanov LA (2009) Structural basis for the mechanism of respiratory complex I. J Biol Chem 284, 29773-83
Hirst J (2009) Towards the molecular mechanism of respiratory complex I. Biochem J 425, 327-39
Lambert AJ, Buckingham JA & Brand MD (2008) Dissociation of superoxide production by mitochondrial complex I from NAD(P)H redox state. FEBS Lett 582, 1711-4
Hirst J, King MS & Pryde KR (2008) The production of reactive oxygen species by complex I. Biochem Soc Trans 36, 976-80
Esterházy D, King MS, Yakovlev G & Hirst J (2008) Production of reactive oxygen species by complex I (NADH:ubiquinone oxidoreductase) from Escherichia coli and comparison to the enzyme from mitochondria. Biochemistry 47, 3964-71
Ross MF, Prime TA, Abakumova I, James AM, Porteous CM, Smith RAJ & Murphy MP (2008) Rapid and extensive uptake and activation of hydrophobic triphenylphosphonium cations within cells. Biochem J 411, 633-45
Reda T, Barker CD & Hirst J (2008) Reduction of the iron-sulfur clusters in mitochondrial NADH:ubiquinone oxidoreductase (complex I) by EuII-DTPA, a very low potential reductant. Biochemistry 47, 8885-93
Reda T, Plugge CM, Abram NJ & Hirst J (2008) Reversible interconversion of carbon dioxide and formate by an electroactive enzyme. Proc Natl Acad Sci U S A 105, 10654-8
Vergani L, Malena A, Sabatelli P, Loro E, Cavallini L, Magalhaes P, Valente L, Bragantini F, Carrara F, Leger B, Poulton J, Russell AP & Holt IJ (2007) Cultured muscle cells display defects of mitochondrial myopathy ameliorated by anti-oxidants. Brain 130, 2715-24
Hurd TR, Prime TA, Harbour ME, Lilley KS & Murphy MP (2007) Detection of reactive oxygen species-sensitive thiol proteins by redox difference gel electrophoresis: implications for mitochondrial redox signaling. J Biol Chem 282, 22040-51
Barker CD, Reda T & Hirst J (2007) The flavoprotein subcomplex of complex I (NADH:ubiquinone oxidoreductase) from bovine heart mitochondria: insights into the mechanisms of NADH oxidation and NAD+ reduction from protein film voltammetry. Biochemistry 46, 3454-64
James AM, Sharpley MS, Manas A-RB, Frerman FE, Hirst J, Smith RAJ & Murphy MP (2007) Interaction of the mitochondria-targeted antioxidant MitoQ with phospholipid bilayers and ubiquinone oxidoreductases. J Biol Chem 282, 14708-18
Worrall JAR, Schlarb-Ridley BG, Reda T, Marcaida MJ, Moorlen RJ, Wastl J, Hirst J, Bendall DS, Luisi BF & Howe CJ (2007) Modulation of heme redox potential in the cytochrome c6 family. J Am Chem Soc 129, 9468-75
Lambert AJ & Brand MD (2007) Research on mitochondria and aging, 2006-2007. Aging Cell 6, 417-20
Baranova EA, Morgan DJ & Sazanov LA (2007) Single particle analysis confirms distal location of subunits NuoL and NuoM in Escherichia coli complex I. J Struct Biol 159, 238-42
Brown SE, Ross MF, Sanjuan-Pla A, Manas A-RB, Smith RAJ & Murphy MP (2007) Targeting lipoic acid to mitochondria: synthesis and characterization of a triphenylphosphonium-conjugated alpha-lipoyl derivative. Free Radic Biol Med 42, 1766-80
Marshall D, Fisher N, Grigic L, Zickermann V, Brandt U, Shannon RJ, Hirst J, Lawrence R & Rich PR (2006) ATR-FTIR redox difference spectroscopy of Yarrowia lipolytica and bovine complex I. Biochemistry 45, 5458-67
Sharpley MS, Shannon RJ, Draghi F & Hirst J (2006) Interactions between phospholipids and NADH:ubiquinone oxidoreductase (complex I) from bovine mitochondria. Biochemistry 45, 241-8
Reda T & Hirst J (2006) Interpreting the catalytic voltammetry of an adsorbed enzyme by considering substrate mass transfer, enzyme turnover, and interfacial electron transport. J Phys Chem B 110, 1394-404
Kussmaul L & Hirst J (2006) The mechanism of superoxide production by NADH:ubiquinone oxidoreductase (complex I) from bovine heart mitochondria. Proc Natl Acad Sci U S A 103, 7607-12
Filipovska A & Murphy MP (2006) Overview of protein glutathionylation. Curr Protoc Toxicol Chapter 6, Unit6.10
Sazanov LA & Hinchliffe P (2006) Structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus. Science 311, 1430-6