Publications

Found 75 results
Filters: Keyword is Oxidative Stress  [Clear All Filters]
2006
Magwere T, West M, Riyahi K, Murphy MP, Smith RAJ & Partridge L (2006) The effects of exogenous antioxidants on lifespan and oxidative stress resistance in Drosophila melanogaster. Mech Ageing Dev 127, 356-70
Pierre F, Peiro G, Taché S, Cross AJ, Bingham SA, Gasc N, Gottardi G, Corpet DE & Guéraud F (2006) New marker of colon cancer risk associated with heme intake: 1,4-dihydroxynonane mercapturic acid. Cancer Epidemiol Biomarkers Prev 15, 2274-9
2005
Meulener M, Whitworth AJ, Armstrong-Gold CE, Rizzu P, Heutink P, Wes PD, Pallanck LJ & Bonini NM (2005) Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson's disease. Curr Biol 15, 1572-7
Greene JC, Whitworth AJ, Andrews LA, Parker TJ & Pallanck LJ (2005) Genetic and genomic studies of Drosophila parkin mutants implicate oxidative stress and innate immune responses in pathogenesis. Hum Mol Genet 14, 799-811
Echtay KS, Pakay JL, Esteves TC & Brand MD (2005) Hydroxynonenal and uncoupling proteins: a model for protection against oxidative damage. Biofactors 24, 119-30
James AM, Cochemé HM, Smith RAJ & Murphy MP (2005) Interactions of mitochondria-targeted and untargeted ubiquinones with the mitochondrial respiratory chain and reactive oxygen species. Implications for the use of exogenous ubiquinones as therapies and experimental tools. J Biol Chem 280, 21295-312
James AM, Cochemé HM & Murphy MP (2005) Mitochondria-targeted redox probes as tools in the study of oxidative damage and ageing. Mech Ageing Dev 126, 982-6
Bianchi P, Pimentel DR, Murphy MP, Colucci WS & Parini A (2005) A new hypertrophic mechanism of serotonin in cardiac myocytes: receptor-independent ROS generation. FASEB J 19, 641-3
Brand MD & Esteves TC (2005) Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3. Cell Metab 2, 85-93
Canoy D, Wareham N, Welch A, Bingham S, Luben R, Day N & Khaw K-T (2005) Plasma ascorbic acid concentrations and fat distribution in 19,068 British men and women in the European Prospective Investigation into Cancer and Nutrition Norfolk cohort study. Am J Clin Nutr 82, 1203-9
2004
Beer SM, Taylor ER, Brown SE, Dahm CC, Costa NJ, Runswick MJ & Murphy MP (2004) Glutaredoxin 2 catalyzes the reversible oxidation and glutathionylation of mitochondrial membrane thiol proteins: implications for mitochondrial redox regulation and antioxidant DEFENSE. J Biol Chem 279, 47939-51
Murphy MP (2004) Investigating mitochondrial radical production using targeted probes. Biochem Soc Trans 32, 1011-4
King A, Gottlieb E, Brooks DG, Murphy MP & Dunaief JL (2004) Mitochondria-derived reactive oxygen species mediate blue light-induced death of retinal pigment epithelial cells. Photochem Photobiol 79, 470-5
Chen K, Thomas SR, Albano A, Murphy MP & Keaney JF (2004) Mitochondrial function is required for hydrogen peroxide-induced growth factor receptor transactivation and downstream signaling. J Biol Chem 279, 35079-86
Green K, Brand MD & Murphy MP (2004) Prevention of mitochondrial oxidative damage as a therapeutic strategy in diabetes. Diabetes 53 Suppl 1, S110-8
2003
Jauslin ML, Meier T, Smith RAJ & Murphy MP (2003) Mitochondria-targeted antioxidants protect Friedreich Ataxia fibroblasts from endogenous oxidative stress more effectively than untargeted antioxidants. FASEB J 17, 1972-4
Saretzki G, Murphy MP & von Zglinicki T (2003) MitoQ counteracts telomere shortening and elongates lifespan of fibroblasts under mild oxidative stress. Aging Cell 2, 141-3
Bedogni B, Pani G, Colavitti R, Riccio A, Borrello S, Murphy M, Smith R, Eboli MLuisa & Galeotti T (2003) Redox regulation of cAMP-responsive element-binding protein and induction of manganous superoxide dismutase in nerve growth factor-dependent cell survival. J Biol Chem 278, 16510-9
Taylor ER, Hurrell F, Shannon RJ, Lin T-K, Hirst J & Murphy MP (2003) Reversible glutathionylation of complex I increases mitochondrial superoxide formation. J Biol Chem 278, 19603-10
2002
James AM & Murphy MP (2002) How mitochondrial damage affects cell function. J Biomed Sci 9, 475-87
Brand MD, Pamplona R, Portero-Otín M, Requena JR, Roebuck SJ, Buckingham JA, Clapham JC & Cadenas S (2002) Oxidative damage and phospholipid fatty acyl composition in skeletal muscle mitochondria from mice underexpressing or overexpressing uncoupling protein 3. Biochem J 368, 597-603
Lin T-K, Hughes G, Muratovska A, Blaikie FH, Brookes PS, Darley-Usmar V, Smith RAJ & Murphy MP (2002) Specific modification of mitochondrial protein thiols in response to oxidative stress: a proteomics approach. J Biol Chem 277, 17048-56
2001
Hwang PM, Bunz F, Yu J, Rago C, Chan TA, Murphy MP, Kelso GF, Smith RA, Kinzler KW & Vogelstein B (2001) Ferredoxin reductase affects p53-dependent, 5-fluorouracil-induced apoptosis in colorectal cancer cells. Nat Med 7, 1111-7
Kelso GF, Porteous CM, Coulter CV, Hughes G, Porteous WK, Ledgerwood EC, Smith RA & Murphy MP (2001) Selective targeting of a redox-active ubiquinone to mitochondria within cells: antioxidant and antiapoptotic properties. J Biol Chem 276, 4588-96
2000
Kajander OA, Rovio AT, Majamaa K, Poulton J, Spelbrink JN, Holt IJ, Karhunen PJ & Jacobs HT (2000) Human mtDNA sublimons resemble rearranged mitochondrial genoms found in pathological states. Hum Mol Genet 9, 2821-35

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