MTCH2: A new regulator of mitochondria function in homeostasis and stress
Mitochondria are highly dynamic organelles that play fundamental roles in pivotal cellular processes including energy production/metabolism, calcium homeostasis, and apoptosis. In our laboratory, we are specifically interested in understanding how these different mitochondrial processes are regulated/coordinated to determine the fate of our cells. Our studies are focused on a novel mitochondrial protein named MTCH2 that acts as a receptor-like protein for pro-apoptotic BID. Interestingly, conditional knockout of MTCH2 in several different mouse tissues results in significant alterations to mitochondria function and structure leading to changes in cell fate and disease outcome. A better understanding of MTCH2’s mechanism of action will likely uncover hidden connections between the many functions of mitochondria.