Molecular wiring of a mitochondrial translation feedback loop
Mitochondrial respiratory chain complexes are mosaics of subunits encoded in either the nuclear or the mitochondrial DNA. For efficient assembly of these complexes, both genetic systems need to be coordinated to supply equal quantities of subunits. We have in the past identified a feedback mechanisms that adjusts mitochondrial synthesis of cytochrome b to levels that can be assembled into a functional complex III. Here, I will present our current work to identify how such a regulatory process works at the molecular level.