Drosophila models of mitochondrial toxic signals
The work by my team focuses on mitochondrial signalling pathways of toxicity. By understanding the basic biology of these processes, we aim to deliver field-changing mechanistic insights into toxicology and disease. The objective of this work is to target mitochondrial signalling pathways to improve neuronal health in models of Parkinson’s disease (PD) and other diseases related to mitochondrial dysfunction. We use the fruit fly, Drosophila melanogaster, as a model system to study organs and tissues with high energetic demand, such as the brain and muscles, that are susceptible to toxic insults.