Featured articles

Rare disease day: 28 February

28 February is the twelfth international Rare Disease Day, coordinated by EURORDIS.

Around this date, awareness-raising activities are taking place all over the world.

The MBU's contribution was a mitochondrial face-painting event - great fun was had by all!

Professor Patrick Chinnery appointed as MRC Clinical Director

Congratulations to Professor Patrick Chinnery, who has been appointed as the MRC's Clinical Director.

Patrick will play a key role in developing, promoting and implementing MRC research programmes, both nationally and internationally.

Patrick is very excited about the opportunities that this new role presents for the translation of laboratory research into improvements in healthcare.

The full press release can be found on the MRC's news page.

A new drug target for tuberculosis

Professor John Walker and his colleagues have solved the first structure of an F1 domain from a bacterial pathogen family, which could lead to the development of new drugs to prevent and cure tuberculosis (TB) to follow on from the recently developed anti-TB drug Bedaquiline which targets the membrane domain of ATP synthase, and is used for treating multi-drug-resistant TB.

ATP (adenosine triphosphate) is the fuel of life and is generated in cellular organisms by an enzyme called ATP synthase.

Atomic resolution cryoEM structures of mammalian respiratory complex I

Researchers at the MRC Mitochondrial Biology Unit, led by Dr Judy Hirst, have used cryoEM to determine structures of mammalian respiratory complex I at atomic resolution - sufficient to see how individual amino acid sidechains change position between two different states of the enzyme.