In their papers published in Cell Metabolism members of Professor Massimo Zeviani's group, and that of Luca Scorrano at the University of Padua have identified a potential therapeutic target for combating mitochondrial disease.
Opa1 overexpression ameliorates the phenotype of two mitochondrial disease mouse models. Cell Metab 21, 845-54
(2015) The OPA1-dependent mitochondrial cristae remodeling pathway controls atrophic, apoptotic, and ischemic tissue damage. Cell Metab 21, 834-44