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Stochastic mutations in the mitochondrial genome (mtDNA) have been linked to many diseases, and their accumulation has been proposed to act as a driving force in the ageing process itself. For the past 15 years the main animal model used to study this phenomenon has been the ‘mutator’ mouse, harbouring a proofreading...

Mitochondria generate the cellular fuel, adenosine triphosphate, or ATP, to sustain complex life. Production of ATP depends on the oxidation of energy rich compounds to produce a chemical potential difference for hydrogen ions (or proton motive force, pmf), across the inner mitochondrial membrane (IMM). Disruption of the...

The 7th Annual Sir John Walker Lecture, ‘Regulation of Growth and Metabolism’, was delivered on Thursday, 30 May 2019, by David Sabatini , MD, PhD. Professor Sabatini is a member of the Whitehead Institute and Professor of Biology at the Massachusetts Institute of Technology (MIT). He studies the pathways that regulate...

On 7 May 2019, Nobel Laureate Professor Sir John Walker FRS, FMedSci was presented with the University of Helsinki Silver Medal , the University's highest award, in recognition of his contributions to bioenergetics and structural biology and for advising the University's Institute of Biotechnology, as a member of its...