Anthony Smith

Anthony Smith

Investigator Scientist

I am a computational biologist with a particular interest in mitochondria and metabolism. One of my projects is building large-scale computer models of central metabolism. My models are integrated with data from biochemical, metabolomic, transcriptomic and proteomic studies to provide a framework to study various conditions and disorders. This can give an insight into complicated phenotypes, help uncover mechanisms, and allow the prediction of interventions that may be of therapeutic benefit. More details can be found here.

I also develop and maintain the MitoMiner database of mammalian mitochondrial localisation evidence. We use machine learning on the data it contains to create our mitochondrial gene list called IMPI.

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Recent publications

Majd H, King MS, Smith AC & Kunji ERS (2018) Pathogenic mutations of the human mitochondrial citrate carrier SLC25A1 lead to impaired citrate export required for lipid, dolichol, ubiquinone and sterol synthesis. Biochim Biophys Acta 1859, 1-7

Smith AC, Eyassu F, Mazat J-P & Robinson AJ (2017) MitoCore: a curated constraint-based model for simulating human central metabolism. BMC Syst Biol 11, 114

Zieliński ŁP, Smith AC, Smith AG & Robinson AJ (2016) Metabolic flexibility of mitochondrial respiratory chain disorders predicted by computer modelling. Mitochondrion 31, 45-55

Smith AC & Robinson AJ (2016) MitoMiner v3.1, an update on the mitochondrial proteomics database. Nucleic Acids Res 44, D1258-61