The following Ph D research projects are available for students to begin study in October 2013 (or possibly, in January 2013 or April 2013):

Structure and function of bioenergetic proteins

• Edmund Kunji - The structural changes of the mitochondrial ADP/ATP carrier in the transport cycle
• Leonid Sazanov - The structure and function of bacterial respiratory complex I
• Judy Hirst - Structure and function of mitochondrial NADH:ubiquinone oxidoreductase (complex I)
• John Walker - Structural and functional studies of the ATP synthase
• Edmund Kunji and Michael Murphy - Mitochondrial glutathione transport

Signalling pathways in mitochondria

• Michael Murphy - Targeting molecules to mitochondria, mitochondrial radical production, thiol redox state and redox signalling
• John Walker - Studies of signalling pathways in mitochondria by proteomic methods
• John Walker - Assembly of respiratory complexes in mitochondria

Genetics

• Michal Minczuk - Genetic manipulation of mitochondrial DNA
  

 Bioinformatics

• Alan Robinson - Computer modelling of mitochondrial metabolism and bioenergetics
• Edmund Kunji and Alan Robinson - Virtual screening and inhibitor design against the mitosomal ADP/ATP carrier of Entamoeba histolytica

For further details about these projects, please contact the appropriate supervisor directly by e-mail. Alternatively, write to Penny Peck, Postgraduate Secretary, MRC Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY or e-mail her at: postgraduate.secretary@mrc-mbu.cam.ac.uk.