The regulation and physiology of mitochondrial proton leak.

TitleThe regulation and physiology of mitochondrial proton leak.
Publication TypeJournal Article
Year of Publication2011
AuthorsDivakaruni, AS, Brand, MD
JournalPhysiology (Bethesda)
Date Published2011 Jun
KeywordsAdenosine Triphosphate, Aging, Animals, Anti-Obesity Agents, Energy Metabolism, Humans, Hypoglycemic Agents, Ion Channels, Membrane Potential, Mitochondrial, Mitochondria, Mitochondrial Membranes, Mitochondrial Proteins, Proton-Motive Force, Uncoupling Protein 1, Uncoupling Protein 2, Uncoupling Protein 3

Mitochondria couple respiration to ATP synthesis through an electrochemical proton gradient. Proton leak across the inner membrane allows adjustment of the coupling efficiency. The aim of this review is threefold: 1) introduce the unfamiliar reader to proton leak and its physiological significance, 2) review the role and regulation of uncoupling proteins, and 3) outline the prospects of proton leak as an avenue to treat obesity, diabetes, and age-related disease.

Alternate JournalPhysiology (Bethesda)
Citation Key10.1152/physiol.00046.2010
PubMed ID21670165