Unraveling the biological roles of reactive oxygen species.

TitleUnraveling the biological roles of reactive oxygen species.
Publication TypeJournal Article
Year of Publication2011
AuthorsMurphy, MP, Holmgren, A, Larsson, N-G, Halliwell, B, Chang, CJ, Kalyanaraman, B, Rhee, SGoo, Thornalley, PJ, Partridge, L, Gems, D, Nyström, T, Belousov, V, Schumacker, PT, Winterbourn, CC
JournalCell Metab
Volume13
Issue4
Pagination361-366
Date Published2011 Apr 06
ISSN1932-7420
KeywordsAntioxidants, Oxidative Stress, Reactive Oxygen Species, Signal Transduction
Abstract

Reactive oxygen species are not only harmful agents that cause oxidative damage in pathologies, they also have important roles as regulatory agents in a range of biological phenomena. The relatively recent development of this more nuanced view presents a challenge to the biomedical research community on how best to assess the significance of reactive oxygen species and oxidative damage in biological systems. Considerable progress is being made in addressing these issues, and here we survey some recent developments for those contemplating research in this area.

DOI10.1016/j.cmet.2011.03.010
Alternate JournalCell Metab.
Citation Key10.1016/j.cmet.2011.03.010
PubMed ID21459321
PubMed Central IDPMC4445605
Grant List081394 / / Wellcome Trust / United Kingdom
BB/D020786/1 / / Biotechnology and Biological Sciences Research Council / United Kingdom
MC_G0901472 / / Medical Research Council / United Kingdom
MC_U105663142 / / Medical Research Council / United Kingdom