Title | Coupling of proton and substrate translocation in the transport cycle of mitochondrial carriers. |
Publication Type | Journal Article |
Year of Publication | 2010 |
Authors | Kunji, ERS, Robinson, AJ |
Journal | Curr Opin Struct Biol |
Volume | 20 |
Issue | 4 |
Pagination | 440-7 |
Date Published | 2010 Aug |
ISSN | 1879-033X |
Keywords | Animals, Binding Sites, Biological Transport, Humans, Mitochondrial Membrane Transport Proteins, Protons |
Abstract | Members of the mitochondrial carrier family are involved in transporting keto acids, amino acids, nucleotides, inorganic ions and co-factors across the mitochondrial inner membrane. The transporters are thought to share the same structural fold, which consists of six trans-membrane alpha-helices and three matrix helices, arranged with threefold pseudo-symmetry. During the transport cycle two salt bridge networks on either side of the central cavity might regulate access to a single substrate binding site in an alternating fashion. In the case of proton-substrate symporters the substrate binding sites contain also negatively charged residues that are proposed to be involved in proton transport. |
DOI | 10.1016/j.sbi.2010.06.004 |
Alternate Journal | Curr. Opin. Struct. Biol. |
Citation Key | 10.1016/j.sbi.2010.06.004 |
PubMed ID | 20598524 |
Grant List | MC_U105663139 / / Medical Research Council / United Kingdom MC_U105674181 / / Medical Research Council / United Kingdom HEALTH-F4-2007-201924 / / Medical Research Council / United Kingdom |