Coupling of proton and substrate translocation in the transport cycle of mitochondrial carriers.

TitleCoupling of proton and substrate translocation in the transport cycle of mitochondrial carriers.
Publication TypeJournal Article
Year of Publication2010
AuthorsKunji, ERS, Robinson, AJ
JournalCurr Opin Struct Biol
Volume20
Issue4
Pagination440-7
Date Published2010 Aug
ISSN1879-033X
KeywordsAnimals, Binding Sites, Biological Transport, Humans, Mitochondrial Membrane Transport Proteins, Protons
Abstract

Members of the mitochondrial carrier family are involved in transporting keto acids, amino acids, nucleotides, inorganic ions and co-factors across the mitochondrial inner membrane. The transporters are thought to share the same structural fold, which consists of six trans-membrane alpha-helices and three matrix helices, arranged with threefold pseudo-symmetry. During the transport cycle two salt bridge networks on either side of the central cavity might regulate access to a single substrate binding site in an alternating fashion. In the case of proton-substrate symporters the substrate binding sites contain also negatively charged residues that are proposed to be involved in proton transport.

DOI10.1016/j.sbi.2010.06.004
Alternate JournalCurr. Opin. Struct. Biol.
Citation Key10.1016/j.sbi.2010.06.004
PubMed ID20598524
Grant ListHEALTH-F4-2007-201924 / / Medical Research Council / United Kingdom
MC_U105663139 / / Medical Research Council / United Kingdom
MC_U105674181 / / Medical Research Council / United Kingdom