The regulation and turnover of mitochondrial uncoupling proteins.

TitleThe regulation and turnover of mitochondrial uncoupling proteins.
Publication TypeJournal Article
Year of Publication2010
AuthorsAzzu, V, Jastroch, M, Divakaruni, AS, Brand, MD
JournalBiochim Biophys Acta
Volume1797
Issue6-7
Pagination785-91
Date Published2010 Jun-Jul
ISSN0006-3002
KeywordsAnimals, Diabetes Mellitus, Energy Metabolism, Gene Expression, Humans, Insulin Resistance, Ion Channels, Mitochondria, Mitochondrial Proteins, Models, Biological, Obesity, Uncoupling Protein 1, Uncoupling Protein 2, Uncoupling Protein 3
Abstract

Uncoupling proteins (UCP1, UCP2 and UCP3) are important in regulating cellular fuel metabolism and as attenuators of reactive oxygen species production through strong or mild uncoupling. The generic function and broad tissue distribution of the uncoupling protein family means that they are increasingly implicated in a range of pathophysiological processes including obesity, insulin resistance and diabetes mellitus, neurodegeneration, cardiovascular disease, immunity and cancer. The significant recent progress describing the turnover of novel uncoupling proteins, as well as current views on the physiological roles and regulation of UCPs, is outlined.

DOI10.1016/j.bbabio.2010.02.035
Alternate JournalBiochim. Biophys. Acta
Citation Key10.1016/j.bbabio.2010.02.035
PubMed ID20211596
PubMed Central IDPMC2891119
Grant ListP01 AG025901-03 / AG / NIA NIH HHS / United States
PL1 AG032118 / AG / NIA NIH HHS / United States
P01 AG025901 / AG / NIA NIH HHS / United States
MC_U105663137 / / Medical Research Council / United Kingdom
P30 AG025708-04 / AG / NIA NIH HHS / United States
UL1 DE019608-03 / DE / NIDCR NIH HHS / United States
/ / Medical Research Council / United Kingdom
P01 AG025901-04 / AG / NIA NIH HHS / United States
UL1 DE019608-02 / DE / NIDCR NIH HHS / United States
UL1 DE019608-02S1 / DE / NIDCR NIH HHS / United States
R01 AG033542 / AG / NIA NIH HHS / United States
UL1 DE019608 / DE / NIDCR NIH HHS / United States
P30 AG025708 / AG / NIA NIH HHS / United States
R01 AG033542-01 / AG / NIA NIH HHS / United States
P30 AG025708-05 / AG / NIA NIH HHS / United States