The on-off switches of the mitochondrial uncoupling proteins.

TitleThe on-off switches of the mitochondrial uncoupling proteins.
Publication TypeJournal Article
Year of Publication2010
AuthorsAzzu, V, Brand, MD
JournalTrends Biochem Sci
Volume35
Issue5
Pagination298-307
Date Published2010 May
ISSN0968-0004
KeywordsAcclimatization, Animals, Humans, Lipid Metabolism, Mitochondria, Proteins, Thermogenesis
Abstract

Mitochondrial uncoupling proteins disengage substrate oxidation from ADP phosphorylation by dissipating the proton electrochemical gradient that is required for ATP synthesis. In doing this, the archetypal uncoupling protein, UCP1, mediates adaptive thermogenesis. By contrast, its paralogues UCP2 and UCP3 are not thought to mediate whole body thermogenesis in mammals. Instead, they have been implicated in a variety of physiological and pathological processes, including protection from oxidative stress, negative regulation of glucose sensing systems and the adaptation of fatty acid oxidation capacity to starving. Although much work has been devoted to how these proteins are activated, little is known of the mechanisms that reverse this activation.

DOI10.1016/j.tibs.2009.11.001
Alternate JournalTrends Biochem. Sci.
Citation Key10.1016/j.tibs.2009.11.001
PubMed ID20006514
PubMed Central IDPMC3640847
Grant ListMC_U105663137 / / Medical Research Council / United Kingdom
P01 AG025901 / AG / NIA NIH HHS / United States
P30 AG025708 / AG / NIA NIH HHS / United States
PL1 AG032118 / AG / NIA NIH HHS / United States