Mitochondrial DNA replication and repair: all a flap.

TitleMitochondrial DNA replication and repair: all a flap.
Publication TypeJournal Article
Year of Publication2009
AuthorsHolt, IJ
JournalTrends Biochem Sci
Date Published2009 Jul
KeywordsAnimals, DNA, DNA Repair, DNA Repair Enzymes, DNA Replication, DNA, Mitochondrial, Humans, Mitochondria, Models, Biological

The mitochondrial genome is dwarfed by its neighbour in the nucleus, and, thus, it has been sensible for far more resources to be invested in the study of nuclear, rather than mitochondrial, DNA metabolism. Furthermore, few researchers have considered using mitochondrial DNA (mtDNA) as a model system for nuclear DNA metabolism. A quick look into the history of mtDNA provides ready answers as to why this was the case; however, recently mitochondria have been found to contain several nuclear replication and repair factors, so is there any potential to adopt the mitochondrion as a tool to unravel some of the intricacies of replication and repair in higher-order eukaryotes? Perhaps it is now time to invite the Cinderella genome to the ball.

Alternate JournalTrends Biochem. Sci.
Citation Key10.1016/j.tibs.2009.03.007
PubMed ID19559620
Grant ListMC_U105663140 / / Medical Research Council / United Kingdom
/ / Biotechnology and Biological Sciences Research Council / United Kingdom