Human polynucleotide phosphorylase, hPNPase, is localized in mitochondria.

TitleHuman polynucleotide phosphorylase, hPNPase, is localized in mitochondria.
Publication TypeJournal Article
Year of Publication2003
AuthorsPiwowarski, J, Grzechnik, P, Dziembowski, A, Dmochowska, A, Minczuk, M, Stepien, PP
JournalJ Mol Biol
Volume329
Issue5
Pagination853-7
Date Published2003 Jun 20
ISSN0022-2836
KeywordsCloning, Molecular, Cytoplasm, Escherichia coli, HeLa Cells, Humans, Microscopy, Fluorescence, Mitochondria, Peptide Fragments, Polyribonucleotide Nucleotidyltransferase, Protein Transport, Recombinant Proteins
Abstract

The human gene encoding a polynucleotide phosphorylase (hPNPase) has been recently identified as strongly up-regulated in two processes leading to irreversible arrest of cell division: progeroid senescence and terminal differentiation. Here, we demonstrate that the hPNPase is localized in mitochondria. Our finding suggests the involvement of mitochondrial RNA metabolism in cellular senescence.

DOI10.1016/s0022-2836(03)00528-x
Alternate JournalJ. Mol. Biol.
Citation Key10.1016/s0022-2836(03)00528-x
PubMed ID12798676