Bactericidal mode of action of plantaricin C.

TitleBactericidal mode of action of plantaricin C.
Publication TypeJournal Article
Year of Publication1996
AuthorsGonzalez, B, Glaasker, E, Kunji, ERS, Driessen, A, Suarez, JE, Konings, WN
JournalAppl Environ Microbiol
Date Published1996 Aug

Plantaricin C is a bacteriocin produced by Lactobacillus plantarum LL441 that kills sensitive cells by acting on the cytoplasmic membrane. In contrast to its lack of impact on immune cells, plantaricin C dissipates the proton motive force and inhibits amino acid transport in sensitive cells. In proteoliposomes, plantaricin C dissipates the transmembrane electrical potential, and in liposomes, it elicits efflux of entrapped carboxy-fluorescein. It is concluded that plantaricin C is a pore-forming bacteriocin that functions in a voltage-independent manner and does not require a specific protein receptor in the target membrane.

Alternate JournalAppl. Environ. Microbiol.
Citation Key1141
PubMed ID16535371
PubMed Central IDPMC1388909