Mitochondrial diseases: a cross-talk between mitochondrial and nuclear genomes.

TitleMitochondrial diseases: a cross-talk between mitochondrial and nuclear genomes.
Publication TypeJournal Article
Year of Publication2009
AuthorsSpinazzola, A, Zeviani, M
JournalAdv Exp Med Biol
Volume652
Pagination69-84
Date Published2009
ISSN0065-2598
KeywordsCell Nucleus, Genome, Mitochondrial, Humans, Mitochondrial Diseases, Mutation
Abstract

More than one billion years ago, mitochondria were free-living prokaryotic organisms with their own DNA. However, during the evolution, ancestral genes have been transferred from the mitochondrial to the nuclear genome so that mtDNA became dependent on numerous nucleus-encoded factors for its integrity, replication and expression. Mutations in any of these factors may alter the cross-talk between the two genomes and cause Mendelian diseases that affect mtDNA integrity or expression.

DOI10.1007/978-90-481-2813-6_6
Alternate JournalAdv. Exp. Med. Biol.
Citation Key10.1007/978-90-481-2813-6_6
PubMed ID20225020