|Title||POLG1 in idiopathic Parkinson disease.|
|Publication Type||Journal Article|
|Year of Publication||2006|
|Authors||Tiangyou, W, Hudson, G, Ghezzi, D, Ferrari, G, Zeviani, M, Burn, DJ, Chinnery, PF|
|Date Published||2006 Nov 14|
|Keywords||Aged, Cohort Studies, DNA Mutational Analysis, DNA Polymerase gamma, DNA-Directed DNA Polymerase, Exons, Female, Gene Frequency, Genetic Markers, Genetic Predisposition to Disease, Genetic Testing, Genetic Variation, Genotype, Humans, Italy, Male, Middle Aged, Mutation, Parkinson Disease, Polymorphism, Genetic, United Kingdom|
We studied POLG1 in 140 UK patients with idiopathic Parkinson disease (PD) and 279 Italian patients with PD and compared them to a UK control group (n = 207) and an Italian control group (n = 285). Our observations do not support a role for common POLG1 genetic variants in PD and indicate that dominant POLG1 mutations are a rare cause of parkinsonism in the general population.
|Grant List||GGP030039 / / Telethon / Italy|