Utility of multimodal evoked potential study and electroencephalography in mitochondrial encephalomyopathy.

TitleUtility of multimodal evoked potential study and electroencephalography in mitochondrial encephalomyopathy.
Publication TypeJournal Article
Year of Publication1998
AuthorsScaioli, V, Antozzi, C, Villani, F, Rimoldi, M, Zeviani, M, Panzica, F, Avanzini, G
JournalItal J Neurol Sci
Volume19
Issue5
Pagination291-300
Date Published1998 Oct
ISSN0392-0461
KeywordsAdult, Electroencephalography, Electroretinography, Evoked Potentials, Evoked Potentials, Auditory, Brain Stem, Evoked Potentials, Somatosensory, Evoked Potentials, Visual, Female, Humans, Male, Middle Aged, Mitochondrial Encephalomyopathies
Abstract

We performed electroencephalography (EEG) and multimodal evoked potential (EP) studies in 16 patients with various forms of mitochondrial encephalomyopathy (ME). The electrophysiological investigations revealed signs of involvement of the peripheral and central nervous system (CNS) in 14 patients, with a high incidence of visual-EP (VEP) alterations, indicative of visual pathway vulnerability in mitochondrial diseases. No specific pattern of abnormalities emerged and, in particular, clinical and laboratory findings did not correlate with each other. EP (particularly VEP and electroretinogram) investigations should be part of the diagnostic work-up of patients with mitochondrial disorders in order to better characterize the clinical picture, disclose involvement of specific sensory systems of the CNS, and assess patients with atypical clinical presentations.

DOI10.1007/bf00713855
Alternate JournalItal J Neurol Sci
Citation Key10.1007/bf00713855
PubMed ID10933449