The myelin basic protein gene is not a major susceptibility locus for multiple sclerosis in Italian patients.

TitleThe myelin basic protein gene is not a major susceptibility locus for multiple sclerosis in Italian patients.
Publication TypeJournal Article
Year of Publication1994
AuthorsEoli, M, Pandolfo, M, Milanese, C, Gasparini, P, Salmaggi, A, Zeviani, M
JournalJ Neurol
Volume241
Issue10
Pagination615-9
Date Published1994 Oct
ISSN0340-5354
KeywordsAdult, Base Sequence, DNA, DNA Primers, Female, Genetic Linkage, Genetic Predisposition to Disease, Humans, Italy, Male, Middle Aged, Molecular Sequence Data, Multiple Sclerosis, Myelin Basic Protein, Polymerase Chain Reaction, Polymorphism, Genetic, Polymorphism, Restriction Fragment Length
Abstract

To verify whether multiallelic polymorphism adjacent to the gene encoding for myelin basic protein is associated with or linked to multiple sclerosis in Italians, we studied 54 sporadic patients, 55 control subjects and 18 families with two or more affected individuals. Allelic typing was carried out by analysis of fragment length polymorphisms after DNA amplification by the polymerase chain reaction. The presence of linkage with the disease was tested according to either autosomal dominant or autosomal recessive modes of inheritance, and with or without the introduction of liability classes accounting for the age of the individuals. Furthermore sib-pair analysis was performed in 11 siblings. No evidence for association or linkage between the myelin basic protein gene polymorphism and multiple sclerosis was found. Our data indicate that in the Italian population the myelin basic protein gene does not play a major role in conferring genetic susceptibility to multiple sclerosis, and suggest that the latter is a heterogeneous phenomenon, possibly influenced by the different ethnic origin of the populations which have been investigated.

DOI10.1007/bf00920626
Alternate JournalJ. Neurol.
Citation Key10.1007/bf00920626
PubMed ID7530769