Bridging the gap between nature and antioxidant setbacks: delivering caffeic acid to mitochondria.

TitleBridging the gap between nature and antioxidant setbacks: delivering caffeic acid to mitochondria.
Publication TypeJournal Article
Year of Publication2015
AuthorsTeixeira, J, Soares, P, Benfeito, S, Murphy, MP, Oliveira, PJ, Borges, F
JournalMethods Mol Biol
Volume1265
Pagination73-83
Date Published2015
ISSN1940-6029
KeywordsAnimals, Antioxidants, Caffeic Acids, Cell Fractionation, Mitochondria, Mitochondria, Liver, Rats
Abstract

As mitochondria have an important role as ATP supplier, cellular ROS producer and apoptosis regulator, these organelles are a promising target for pharmacological intervention in the treatment and management of several diseases. Consequently, research on mitochondria-targeted drugs, which exclude other intracellular structures or extracellular processes, is becoming a hot topic. One approach to address the specific targeting is to conjugate bioactive molecules to a lipophilic cation such as the triphenylphosphonium (TPP(+)). In this chapter, the development of a new antioxidant based on the dietary cinnamic acid-caffeic acid-is described as well as the demonstration of its mitochondriotropic activity.

DOI10.1007/978-1-4939-2288-8_6
Alternate JournalMethods Mol. Biol.
Citation Key10.1007/978-1-4939-2288-8_6
PubMed ID25634268
Grant ListMC_U105663142 / / Medical Research Council / United Kingdom