Fruit, vegetables, and colorectal cancer risk: the European Prospective Investigation into Cancer and Nutrition.

TitleFruit, vegetables, and colorectal cancer risk: the European Prospective Investigation into Cancer and Nutrition.
Publication TypeJournal Article
Year of Publication2009
Authorsvan Duijnhoven, FJB, H Bueno-de-Mesquita, B, Ferrari, P, Jenab, M, Boshuizen, HC, Ros, MM, Casagrande, C, Tjønneland, A, Olsen, A, Overvad, K, Thorlacius-Ussing, O, Clavel-Chapelon, F, Boutron-Ruault, M-C, Morois, S, Kaaks, R, Linseisen, J, Boeing, H, Nöthlings, U, Trichopoulou, A, Trichopoulos, D, Misirli, G, Palli, D, Sieri, S, Panico, S, Tumino, R, Vineis, P, Peeters, PHm, van Gils, CH, Ocké, MC, Lund, iv, E, Engeset, D, Skeie, G, Suárez, LRodríguez, González, CA, Sánchez, M-J, Dorronsoro, M, Navarro, C, Barricarte, A, Berglund, G, Manjer, J, Hallmans, G, Palmqvist, R, Bingham, SA, Khaw, K-T, Key, TJ, Allen, NE, Boffetta, P, Slimani, N, Rinaldi, S, Gallo, V, Norat, T, Riboli, E
JournalAm J Clin Nutr
Volume89
Issue5
Pagination1441-52
Date Published2009 May
ISSN1938-3207
KeywordsColorectal Neoplasms, Diet, Environment, Europe, Female, Follow-Up Studies, Fruit, Humans, Incidence, Life Style, Male, Patient Selection, Reproducibility of Results, Surveys and Questionnaires, Time Factors, Vegetables
Abstract

BACKGROUND: A high consumption of fruit and vegetables is possibly associated with a decreased risk of colorectal cancer (CRC). However, the findings to date are inconsistent.OBJECTIVE: We examined the relation between self-reported usual consumption of fruit and vegetables and the incidence of CRC.DESIGN: In the European Prospective Investigation into Cancer and Nutrition (EPIC), 452,755 subjects (131,985 men and 320,770 women) completed a dietary questionnaire in 1992-2000 and were followed up for cancer incidence and mortality until 2006. A multivariate Cox proportional hazard model was used to estimate adjusted hazard ratios (HRs) and 95% CIs.RESULTS: After an average follow-up of 8.8 y, 2,819 incident CRC cases were reported. Consumption of fruit and vegetables was inversely associated with CRC in a comparison of the highest with the lowest EPIC-wide quintile of consumption (HR: 0.86; 95% CI: 0.75, 1.00; P for trend = 0.04), particularly with colon cancer risk (HR: 0.76; 95% CI: 0.63, 0.91; P for trend < 0.01). Only after exclusion of the first 2 y of follow-up were these findings corroborated by calibrated continuous analyses for a 100-g increase in consumption: HRs of 0.95 (95% CI: 0.91, 1.00; P = 0.04) and 0.94 (95% CI: 0.89, 0.99; P = 0.02), respectively. The association between fruit and vegetable consumption and CRC risk was inverse in never and former smokers, but positive in current smokers. This modifying effect was found for fruit and vegetables combined and for vegetables alone (P for interaction < 0.01 for both).CONCLUSIONS: These findings suggest that a high consumption of fruit and vegetables is associated with a reduced risk of CRC, especially of colon cancer. This effect may depend on smoking status.

DOI10.3945/ajcn.2008.27120
Alternate JournalAm. J. Clin. Nutr.
Citation Key10.3945/ajcn.2008.27120
PubMed ID19339391
Grant List / / British Heart Foundation / United Kingdom
/ / Department of Health / United Kingdom
MC_U105630924 / / Medical Research Council / United Kingdom
/ / Cancer Research UK / United Kingdom
G0401527 / / Medical Research Council / United Kingdom
/ / Wellcome Trust / United Kingdom