Lifetime and baseline alcohol intake and risk of cancer of the upper aero-digestive tract in the European Prospective Investigation into Cancer and Nutrition (EPIC) study.

TitleLifetime and baseline alcohol intake and risk of cancer of the upper aero-digestive tract in the European Prospective Investigation into Cancer and Nutrition (EPIC) study.
Publication TypeJournal Article
Year of Publication2009
AuthorsWeikert, C, Dietrich, T, Boeing, H, Bergmann, MM, Boutron-Ruault, MChristine, Clavel-Chapelon, F, Allen, N, Key, T, Lund, iv, E, Olsen, A, Tjønneland, A, Overvad, K, Rohrmann, S, Linseisen, J, Pischon, T, Trichopoulou, A, Weinehall, L, Johansson, I, Sánchez, M-J, Agudo, A, Barricarte, A, Amiano, P, Chirlaque, M-D, J Quirós, R, Wirfalt, E, Peeters, PH, H Bueno-de-Mesquita, B, Vrieling, A, Pala, V, Palli, D, Vineis, P, Tumino, R, Panico, S, Bingham, S, Khaw, K-T, Norat, T, Jenab, M, Ferrari, P, Slimani, N, Riboli, E
JournalInt J Cancer
Volume125
Issue2
Pagination406-12
Date Published2009 Jul 15
ISSN1097-0215
KeywordsAlcohol Drinking, Carcinoma, Squamous Cell, Esophageal Neoplasms, Europe, Female, Humans, Laryngeal Neoplasms, Male, Mouth Neoplasms, Pharyngeal Neoplasms, Proportional Hazards Models, Prospective Studies, Risk Factors
Abstract

Recent alcohol consumption is an established risk factor for squamous cell carcinoma (SCC) of the upper aero-digestive tract. In contrast, the role of lifetime exposure to alcohol with regard to risk of SCC is not well established. Historical data on alcohol use are available in 271,253 participants of the European Prospective Investigation into Cancer and Nutrition (EPIC). During 2,330,381 person years, 392 incident SCC cases (279 men and 113 women) were identified. Cox regression was applied to model sex-specific associations between lifetime alcohol intake and SCC risk adjusting for potential confounders including smoking. Compared to men who drank 0.1-6.0 g/day alcohol at lifetime, the relative risks (RR) for developing SCC were significantly increased for men who drank 30.1-60.0 g/day (RR 1.65, 95% confidence interval:1.00-2.71), 60.1-96.0 g/day (RR 2.20, 95%CI 1.23-3.95), and >96.0 g/day, (RR 4.63, 95% CI 2.52-8.48), and for former drinkers (RR 4.14, 95%CI 2.38-7.19). These risk estimates did not considerably change when baseline alcohol intake was analyzed. Compared to women who drank 0.1-6.0 g/day alcohol intake at lifetime, the RR were significantly increased for women who drank >30 g/d (RR 6.05, 95%CI 2.98-12.3). Applying similar categories, the relative risk for baseline alcohol intake was 3.26 (95%CI 1.82-5.87). We observed a stronger association between alcohol intake at lifetime and risk of SCC in women compared to men (p for interaction = 0.045). The strong dose-response relation for lifetime alcohol use underscores that alcohol is an important risk factor of SCC of the upper aero-digestive tract throughout life.

DOI10.1002/ijc.24393
Alternate JournalInt. J. Cancer
Citation Key10.1002/ijc.24393
PubMed ID19378340
Grant List / / British Heart Foundation / United Kingdom
/ / Department of Health / United Kingdom
/ / Cancer Research UK / United Kingdom
G0401527 / / Medical Research Council / United Kingdom
/ / Wellcome Trust / United Kingdom