Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer.

TitleGenome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer.
Publication TypeJournal Article
Year of Publication2009
AuthorsAmundadottir, L, Kraft, P, Stolzenberg-Solomon, RZ, Fuchs, CS, Petersen, GM, Arslan, AA, H Bueno-de-Mesquita, B, Gross, M, Helzlsouer, K, Jacobs, EJ, LaCroix, A, Zheng, W, Albanes, D, Bamlet, W, Berg, CD, Berrino, F, Bingham, S, Buring, JE, Bracci, PM, Canzian, F, Clavel-Chapelon, F, Clipp, S, Cotterchio, M, de Andrade, M, Duell, EJ, Fox, JW, Gallinger, S, J Gaziano, M, Giovannucci, EL, Goggins, M, González, CA, Hallmans, G, Hankinson, SE, Hassan, M, Holly, EA, Hunter, DJ, Hutchinson, A, Jackson, R, Jacobs, KB, Jenab, M, Kaaks, R, Klein, AP, Kooperberg, C, Kurtz, RC, Li, D, Lynch, SM, Mandelson, M, McWilliams, RR, Mendelsohn, JB, Michaud, DS, Olson, SH, Overvad, K, Patel, AV, Peeters, PHM, Rajkovic, A, Riboli, E, Risch, HA, Shu, X-O, Thomas, G, Tobias, GS, Trichopoulos, D, Van Den Eeden, SK, Virtamo, J, Wactawski-Wende, J, Wolpin, BM, Yu, H, Yu, K, Zeleniuch-Jacquotte, A, Chanock, SJ, Hartge, P, Hoover, RN
JournalNat Genet
Volume41
Issue9
Pagination986-90
Date Published2009 Sep
ISSN1546-1718
KeywordsABO Blood-Group System, Alleles, Case-Control Studies, Chromosomes, Human, Pair 9, Cohort Studies, Female, Gene Frequency, Genetic Predisposition to Disease, Genetic Variation, Genome-Wide Association Study, Genotype, Haplotypes, Humans, Introns, Linkage Disequilibrium, Logistic Models, Male, Odds Ratio, Pancreatic Neoplasms, Polymorphism, Single Nucleotide, Prospective Studies, Risk Factors, United States
Abstract

We conducted a two-stage genome-wide association study of pancreatic cancer, a cancer with one of the lowest survival rates worldwide. We genotyped 558,542 SNPs in 1,896 individuals with pancreatic cancer and 1,939 controls drawn from 12 prospective cohorts plus one hospital-based case-control study. We conducted a combined analysis of these groups plus an additional 2,457 affected individuals and 2,654 controls from eight case-control studies, adjusting for study, sex, ancestry and five principal components. We identified an association between a locus on 9q34 and pancreatic cancer marked by the SNP rs505922 (combined P = 5.37 x 10(-8); multiplicative per-allele odds ratio 1.20; 95% confidence interval 1.12-1.28). This SNP maps to the first intron of the ABO blood group gene. Our results are consistent with earlier epidemiologic evidence suggesting that people with blood group O may have a lower risk of pancreatic cancer than those with groups A or B.

DOI10.1038/ng.429
Alternate JournalNat. Genet.
Citation Key10.1038/ng.429
PubMed ID19648918
PubMed Central IDPMC2839871
Grant ListP50 CA102701-08 / CA / NCI NIH HHS / United States
R01 CA082729 / CA / NCI NIH HHS / United States
P50 CA062924 / CA / NCI NIH HHS / United States
Z01 CP010193-01 / / Intramural NIH HHS / United States
P50 CA062924-140011 / CA / NCI NIH HHS / United States
R01 CA124908 / CA / NCI NIH HHS / United States
P50 CA102701 / CA / NCI NIH HHS / United States
P50 CA062924-150011 / CA / NCI NIH HHS / United States
P50 CA062924-160011 / CA / NCI NIH HHS / United States
R01 CA097193 / CA / NCI NIH HHS / United States