Consumption of vegetables and fruit and the risk of bladder cancer in the European Prospective Investigation into Cancer and Nutrition.

TitleConsumption of vegetables and fruit and the risk of bladder cancer in the European Prospective Investigation into Cancer and Nutrition.
Publication TypeJournal Article
Year of Publication2009
AuthorsBüchner, FL, H Bueno-de-Mesquita, B, Ros, MM, Kampman, E, Egevad, L, Overvad, K, Raaschou-Nielsen, O, Tjønneland, A, Roswall, N, Clavel-Chapelon, F, Boutron-Ruault, M-C, Touillaud, M, Chang-Claude, J, Kaaks, R, Boeing, H, Weikert, S, Trichopoulou, A, Lagiou, P, Trichopoulos, D, Palli, D, Sieri, S, Vineis, P, Tumino, R, Panico, S, Vrieling, A, Peeters, PHM, van Gils, CH, Lund, iv, E, Gram, IT, Engeset, D, Martinez, C, González, CA, Larrañaga, N, Ardanaz, E, Navarro, C, Rodriguez, L, Manjer, J, Ehrnström, RA, Hallmans, G, Ljungberg, B, Allen, NE, Roddam, AW, Bingham, S, Khaw, K-T, Slimani, N, Boffetta, P, Jenab, M, Mouw, T, Michaud, DS, Kiemeney, LALM, Riboli, E
JournalInt J Cancer
Volume125
Issue11
Pagination2643-51
Date Published2009 Dec 1
ISSN1097-0215
KeywordsAdult, Aged, Cohort Studies, Diet, Female, Follow-Up Studies, Fruit, Humans, Male, Middle Aged, Prospective Studies, Risk Factors, Urinary Bladder Neoplasms, Vegetables
Abstract

Previous epidemiologic studies found inconsistent associations between vegetables and fruit consumption and the risk of bladder cancer. We therefore investigated the association between vegetable and fruit consumption and the risk of bladder cancer among participants of the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Data on food consumption and complete follow-up for cancer occurrence was available for a total of 478,533 participants, who were recruited in 10 European countries. Estimates of rate ratios were obtained by Cox proportional hazard models, stratified by age at recruitment, gender and study centre, and adjusted for total energy intake, smoking status, duration of smoking and lifetime intensity of smoking. A calibration study in a subsample was used to control for dietary measurement errors. After a mean follow-up of 8.7 years, 1015 participants were newly diagnosed with bladder cancer. Increments of 100 g/day in fruit and vegetable consumption combined did not affect bladder cancer risk (i.e., calibrated HR = 0.98; 95%CI: 0.95-1.01). Borderline statistically significant lower bladder cancer risks were found among never smokers with increased consumption of fruit and vegetables combined (HR = 0.94 95%CI: 0.87-1.00 with increments of 100 g/day; calibrated HR = 0.92 95%CI 0.79-1.06) and increased consumption of apples and pears (hard fruit; calibrated HR = 0.90 95%CI: 0.82-0.98 with increments of 25 g/day). For none of the associations a statistically significant interaction with smoking status was found. Our findings do not support an effect of fruit and vegetable consumption, combined or separately, on bladder cancer risk.

DOI10.1002/ijc.24582
Alternate JournalInt. J. Cancer
Citation Key10.1002/ijc.24582
PubMed ID19618458
Grant ListG0401527 / / Medical Research Council / United Kingdom
G0801056B / / Medical Research Council / United Kingdom
/ / Cancer Research UK / United Kingdom
/ / British Heart Foundation / United Kingdom
/ / Department of Health / United Kingdom
/ / Wellcome Trust / United Kingdom
/ / Medical Research Council / United Kingdom