Fruits and vegetables consumption and the risk of histological subtypes of lung cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC).

TitleFruits and vegetables consumption and the risk of histological subtypes of lung cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC).
Publication TypeJournal Article
Year of Publication2010
AuthorsBüchner, FL, Bueno-de-Mesquita, HB, Linseisen, J, Boshuizen, HC, Kiemeney, LALM, Ros, MM, Overvad, K, Hansen, L, Tjonneland, A, Raaschou-Nielsen, O, Clavel-Chapelon, F, Boutron-Ruault, M-C, Touillaud, M, Kaaks, R, Rohrmann, S, Boeing, H, Nöthlings, U, Trichopoulou, A, Zylis, D, Dilis, V, Palli, D, Sieri, S, Vineis, P, Tumino, R, Panico, S, Peeters, PHM, van Gils, CH, Lund, E, Gram, IT, Braaten, T, Martinez, C, Agudo, A, Arriola, L, Ardanaz, E, Navarro, C, Rodríguez, L, Manjer, J, Wirfält, E, Hallmans, G, Rasmuson, T, Key, TJ, Roddam, AW, Bingham, S, Khaw, K-T, Slimani, N, Bofetta, P, Byrnes, G, Norat, T, Michaud, D, Riboli, E
JournalCancer Causes Control
Volume21
Issue3
Pagination357-71
Date Published2010 Mar
ISSN1573-7225
KeywordsAdenocarcinoma, Adult, Antioxidants, Carcinoma, Non-Small-Cell Lung, Carcinoma, Small Cell, Europe, Female, Fruit, Humans, Lung Neoplasms, Male, Middle Aged, Multivariate Analysis, Odds Ratio, Proportional Hazards Models, Prospective Studies, Research Design, Smoking, Vegetables, Young Adult
Abstract

OBJECTIVE: To examine the association between fruit and vegetable consumption and risk of different histological subtypes of lung cancer among participants of the European Prospective Investigation into Cancer and Nutrition study.

METHODS: Multivariable Cox proportional hazard models were used to analyze the data. A calibration study in a subsample was used to reduce dietary measurement errors.

RESULTS: During a mean follow-up of 8.7 years, 1,830 incident cases of lung cancer (574 adenocarcinoma, 286 small cell, 137 large cell, 363 squamous cell, 470 other histologies) were identified. In line with our previous conclusions, we found that after calibration a 100 g/day increase in fruit and vegetables consumption was associated with a reduced lung cancer risk (HR 0.94; 95% CI 0.89-0.99). This was also seen among current smokers (HR 0.93; 95% CI 0.90-0.97). Risks of squamous cell carcinomas in current smokers were reduced for an increase of 100 g/day of fruit and vegetables combined (HR 0.85; 95% CI 0.76-0.94), while no clear effects were seen for the other histological subtypes.

CONCLUSION: We observed inverse associations between the consumption of vegetables and fruits and risk of lung cancer without a clear effect on specific histological subtypes of lung cancer. In current smokers, consumption of vegetables and fruits may reduce lung cancer risk, in particular the risk of squamous cell carcinomas.

DOI10.1007/s10552-009-9468-y
Alternate JournalCancer Causes Control
Citation Key10.1007/s10552-009-9468-y
PubMed ID19924549
PubMed Central IDPMC2835631
Grant List11692 / / Cancer Research UK / United Kingdom
G0401527 / / Medical Research Council / United Kingdom
G0801056B / / Medical Research Council / United Kingdom
/ / Medical Research Council / United Kingdom
/ / British Heart Foundation / United Kingdom
/ / Cancer Research UK / United Kingdom
/ / Department of Health / United Kingdom
/ / Wellcome Trust / United Kingdom