Animal and human studies with the mitochondria-targeted antioxidant MitoQ.

TitleAnimal and human studies with the mitochondria-targeted antioxidant MitoQ.
Publication TypeJournal Article
Year of Publication2010
AuthorsSmith, RAJ, Murphy, MP
JournalAnn N Y Acad Sci
Volume1201
Pagination96-103
Date Published2010 Jul
ISSN1749-6632
KeywordsAdministration, Oral, Animals, Antioxidants, Cations, Clinical Trials, Phase II as Topic, Disease Models, Animal, Fatty Liver, Humans, Liver Diseases, Mice, Mitochondria, Organophosphorus Compounds, Oxidative Stress, Rats, Treatment Outcome, Ubiquinone
Abstract

As mitochondrial oxidative damage contributes to a wide range of human diseases, antioxidants designed to be accumulated by mitochondria in vivo have been developed. The most extensively studied of these mitochondria-targeted antioxidants is MitoQ, which contains the antioxidant quinone moiety covalently attached to a lipophilic triphenylphosphonium cation. MitoQ has now been used in a range of in vivo studies in rats and mice and in two phase II human trials. Here, we review what has been learned from these animal and human studies with MitoQ.

DOI10.1111/j.1749-6632.2010.05627.x
Alternate JournalAnn. N. Y. Acad. Sci.
Citation Key10.1111/j.1749-6632.2010.05627.x
PubMed ID20649545
Grant ListMC_U105663142 / / Medical Research Council / United Kingdom