Diverse mechanisms for activation of Wnt signalling in the ovarian tumour microenvironment.

TitleDiverse mechanisms for activation of Wnt signalling in the ovarian tumour microenvironment.
Publication TypeJournal Article
Year of Publication2011
AuthorsBarbolina, MV, Burkhalter, RJ, M Stack, S
JournalBiochem J
Volume437
Issue1
Pagination1-12
Date Published2011 Jul 01
ISSN1470-8728
Keywordsbeta Catenin, Female, Humans, Models, Biological, Ovarian Neoplasms, Signal Transduction, Tumor Microenvironment, Wnt Proteins
Abstract

Wnt signalling pathways have been shown to play key roles in both normal development and tumorigenesis. Progression of many human cancers is associated with defined mutations in Wnt pathway components that result in dysregulated β-catenin-mediated gene transcription. Although Wnt pathway mutations are rare in epithelial ovarian cancer (with the exception of the endometrioid histotype), accumulating evidence supports a role for Wnt signalling in ovarian tumorigenesis in the absence of genetic mutations. The present review summarizes evidence in support of activated Wnt signalling in ovarian tumours and discusses alternative mechanisms for Wnt pathway activation in the ovarian tumour microenvironment.

DOI10.1042/BJ20110112
Alternate JournalBiochem. J.
Citation Key10.1042/BJ20110112
PubMed ID21668411
PubMed Central IDPMC3133882
Grant ListR01 CA086984 / CA / NCI NIH HHS / United States
R01 CA109545 / CA / NCI NIH HHS / United States
CA086984-11S1 / CA / NCI NIH HHS / United States