Arabidopsis calcium-binding mitochondrial carrier proteins as potential facilitators of mitochondrial ATP-import and plastid SAM-import.

TitleArabidopsis calcium-binding mitochondrial carrier proteins as potential facilitators of mitochondrial ATP-import and plastid SAM-import.
Publication TypeJournal Article
Year of Publication2011
AuthorsStael, S, Rocha, AG, Robinson, AJ, Kmiecik, P, Vothknecht, UC, Teige, M
JournalFEBS Lett
Volume585
Issue24
Pagination3935-40
Date Published2011 Dec 15
ISSN1873-3468
KeywordsAdenosine Triphosphate, Amino Acid Sequence, Arabidopsis, Arabidopsis Proteins, Calcium, Calcium Signaling, Calcium-Binding Proteins, EF Hand Motifs, Genome, Plant, Mitochondria, Molecular Sequence Data, Phylogeny, Plastids, Protein Transport, S-Adenosylmethionine, Substrate Specificity
Abstract

Chloroplasts and mitochondria are central to crucial cellular processes in plants and contribute to a whole range of metabolic pathways. The use of calcium ions as a secondary messenger in and around organelles is increasingly appreciated as an important mediator of plant cell signaling, enabling plants to develop or to acclimatize to changing environmental conditions. Here, we have studied the four calcium-dependent mitochondrial carriers that are encoded in the Arabidopsis genome. An unknown substrate carrier, which was previously found to localize to chloroplasts, is proposed to present a calcium-dependent S-adenosyl methionine carrier. For three predicted ATP/phosphate carriers, we present experimental evidence that they can function as mitochondrial ATP-importers.

DOI10.1016/j.febslet.2011.10.039
Alternate JournalFEBS Lett.
Citation Key10.1016/j.febslet.2011.10.039
PubMed ID22062157
Grant ListMC_U105674181 / / Medical Research Council / United Kingdom