Signaling takes a breath--new quantitative perspectives on bioenergetics and signal transduction.

TitleSignaling takes a breath--new quantitative perspectives on bioenergetics and signal transduction.
Publication TypeJournal Article
Year of Publication2001
AuthorsKrauss, S, Brand, MD, Buttgereit, F
JournalImmunity
Volume15
Issue4
Pagination497-502
Date Published2001 Oct
ISSN1074-7613
KeywordsAdenosine Triphosphate, Animals, Calcineurin, Calcium Signaling, Energy Metabolism, Humans, Lymphocyte Activation, MAP Kinase Signaling System, Models, Immunological, Protein Kinase C, Rats, Signal Transduction, T-Lymphocytes
Abstract

Immune cells are in constant need of energy for both basic housekeeping and specific immune functions. Increased energy demand during lymphocyte stimulation is coordinated by signal transduction pathways. This review explores the interface between lymphocyte signaling and energy metabolism. In particular, it discusses recent work that allows weighing signaling routes with respect to their role in the regulation of energy metabolism during lymphocyte activation.

DOI10.1016/s1074-7613(01)00205-9
Alternate JournalImmunity
Citation Key10.1016/s1074-7613(01)00205-9
PubMed ID11672532