Sequence similarity between stereocilin and otoancorin points to a unified mechanism for mechanotransduction in the mammalian inner ear.

TitleSequence similarity between stereocilin and otoancorin points to a unified mechanism for mechanotransduction in the mammalian inner ear.
Publication TypeJournal Article
Year of Publication2002
AuthorsJovine, L, Park, J, Wassarman, PM
JournalBMC Cell Biol
Volume3
Pagination28
Date Published2002 Nov 25
ISSN1471-2121
KeywordsAmino Acid Sequence, Animals, GPI-Linked Proteins, Hair Cells, Auditory, Inner, Humans, Immunohistochemistry, Mammals, Mechanotransduction, Cellular, Membrane Proteins, Models, Biological, Molecular Sequence Data, Otolithic Membrane, Proteins, Sequence Alignment, Sequence Homology, Amino Acid, Tectorial Membrane
Abstract

BACKGROUND: Interaction between hair cells and acellular gels of the mammalian inner ear, the tectorial and otoconial membranes, is crucial for mechanoreception. Recently, otoancorin was suggested to be a mediator of gel attachment to nonsensory cells, but the molecular components of the interface between gels and sensory cells remain to be identified.HYPOTHESIS: We report that the inner ear protein stereocilin is related in sequence to otoancorin and, based on its localisation and predicted GPI-anchoring, may mediate attachment of the tectorial and otoconial membranes to sensory hair bundles.TESTING: It is expected that antibodies directed against stereocilin would specifically label sites of contact between sensory hair cells and tectorial/otoconial membranes of the inner ear.IMPLICATIONS: Our findings support a unified molecular mechanism for mechanotransduction, with stereocilin and otoancorin defining a new protein family responsible for the attachment of acellular gels to both sensory and nonsensory cells of the inner ear.

DOI10.1186/1471-2121-3-28
Alternate JournalBMC Cell Biol.
Citation Key10.1186/1471-2121-3-28
PubMed ID12445334
PubMed Central IDPMC139993
Grant ListR01 HD035105 / HD / NICHD NIH HHS / United States
HD35105 / HD / NICHD NIH HHS / United States