Interactions of mitochondrial thiols with nitric oxide.

TitleInteractions of mitochondrial thiols with nitric oxide.
Publication TypeJournal Article
Year of Publication2003
AuthorsCosta, NJ, Dahm, CC, Hurrell, F, Taylor, ER, Murphy, MP
JournalAntioxid Redox Signal
Volume5
Issue3
Pagination291-305
Date Published2003 Jun
ISSN1523-0864
KeywordsAnimals, Glutathione, Humans, Mitochondria, Nitric Oxide, Oxidation-Reduction, Oxidoreductases, Sulfhydryl Compounds
Abstract

The interaction of nitric oxide (NO) with mitochondria is of pathological significance and is also a potential mechanism for the regulation of mitochondrial function. Some of the ways in which NO may affect mitochondria are by reacting with low-molecular-weight thiols such as glutathione and with protein thiols. However, the detailed mechanisms and the consequences of these interactions for mitochondria are uncertain. Here we review mitochondrial thiol metabolism, outline how NO and its metabolites interact with thiols, and discuss the implications of these reactions for mitochondrial and cell function.

DOI10.1089/152308603322110878
Alternate JournalAntioxid. Redox Signal.
Citation Key10.1089/152308603322110878
PubMed ID12880484