Interactions of mitochondrial thiols with nitric oxide.

TitleInteractions of mitochondrial thiols with nitric oxide.
Publication TypeJournal Article
Year of Publication2003
AuthorsCosta, NJ, Dahm, CC, Hurrell, F, Taylor, ER, Murphy, MP
JournalAntioxid Redox Signal
Date Published2003 Jun
KeywordsAnimals, Glutathione, Humans, Mitochondria, Nitric Oxide, Oxidation-Reduction, Oxidoreductases, Sulfhydryl Compounds

The interaction of nitric oxide (NO) with mitochondria is of pathological significance and is also a potential mechanism for the regulation of mitochondrial function. Some of the ways in which NO may affect mitochondria are by reacting with low-molecular-weight thiols such as glutathione and with protein thiols. However, the detailed mechanisms and the consequences of these interactions for mitochondria are uncertain. Here we review mitochondrial thiol metabolism, outline how NO and its metabolites interact with thiols, and discuss the implications of these reactions for mitochondrial and cell function.

Alternate JournalAntioxid. Redox Signal.
Citation Key10.1089/152308603322110878
PubMed ID12880484