Macrophage migration inhibitory factor and the risk of myocardial infarction or death due to coronary artery disease in adults without prior myocardial infarction or stroke: the EPIC-Norfolk Prospective Population study.

TitleMacrophage migration inhibitory factor and the risk of myocardial infarction or death due to coronary artery disease in adults without prior myocardial infarction or stroke: the EPIC-Norfolk Prospective Population study.
Publication TypeJournal Article
Year of Publication2004
AuthorsS Boekholdt, M, Peters, RJG, Day, NE, Luben, R, Bingham, SA, Wareham, NJ, C Hack, E, Reitsma, PH, Khaw, K-T
JournalAm J Med
Volume117
Issue6
Pagination390-7
Date Published2004 Sep 15
ISSN0002-9343
KeywordsAdult, Aged, Biological Markers, Blood Pressure, C-Reactive Protein, Case-Control Studies, Cholesterol, HDL, Coronary Artery Disease, Female, Follow-Up Studies, Great Britain, Humans, Macrophage Migration-Inhibitory Factors, Male, Middle Aged, Myocardial Infarction, Prospective Studies, Risk Factors, Sex Factors, Stroke, Survival Analysis
Abstract

PURPOSE: To determine whether plasma levels of macrophage migration inhibitory factor, a proinflammatory cytokine involved in atherogenesis, are predictive of myocardial infarction or death from coronary artery disease.

METHODS: We performed a prospective case-control study nested in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk cohort. We selected men and women who did not report a history of myocardial infarction or stroke at baseline. Baseline concentrations of macrophage migration inhibitory factor were measured among 777 patients who had a myocardial infarction or died of coronary artery disease during follow-up, and 1554 matched controls who remained free of coronary artery disease.

RESULTS: Baseline macrophage migration inhibitory factor concentrations were higher in cases than controls (median, 107.4 microg/L vs. 90.7 microg/L, P = 0.001). The risk of myocardial infarction or death from coronary artery disease increased with increasing quartiles of macrophage migration inhibitory factor (P for linearity

CONCLUSION: Prospective data suggest that the relation between macrophage migration inhibitory factor and the risk of myocardial infarction or death due to coronary artery disease in adults without a history of myocardial infarction or stroke is not very strong. However, the data support a regulatory role for macrophage migration inhibitory factor in the process of atherosclerosis.

DOI10.1016/j.amjmed.2004.04.010
Alternate JournalAm. J. Med.
Citation Key10.1016/j.amjmed.2004.04.010
PubMed ID15380495