|Title||IL-8 plasma concentrations and the risk of future coronary artery disease in apparently healthy men and women: the EPIC-Norfolk prospective population study.|
|Publication Type||Journal Article|
|Year of Publication||2004|
|Authors||S Boekholdt, M, Peters, RJG, C Hack, E, Day, NE, Luben, R, Bingham, SA, Wareham, NJ, Reitsma, PH, Khaw, K-T|
|Journal||Arterioscler Thromb Vasc Biol|
|Date Published||2004 Aug|
|Keywords||Aged, Biological Markers, C-Reactive Protein, Case-Control Studies, Cohort Studies, Comorbidity, Coronary Disease, England, Female, Humans, Hypertension, Interleukin-8, Interleukins, Leukocyte Count, Lipids, Lipoproteins, Male, Middle Aged, Obesity, Odds Ratio, Predictive Value of Tests, Prospective Studies, Risk, Risk Factors, Smoking, Tumor Necrosis Factor-alpha|
OBJECTIVE: To study the role of IL-8 in predicting future coronary artery disease (CAD) in apparently healthy men and women.
METHODS AND RESULTS: A nested case-control study was performed in the prospective EPIC-Norfolk population study. We measured baseline IL-8 concentrations among 785 apparently healthy individuals in whom fatal or nonfatal CAD developed during follow-up and 1570 matched controls. Baseline IL-8 concentrations were higher in cases than in matched controls (3.5 pg/mL versus 3.1 pg/mL, P=0.001). The risk of future CAD increased with increasing quartiles of IL-8 (P linearity
CONCLUSIONS: We conclude that among apparently healthy men and women, elevated levels of IL-8 are associated with an increased risk of future CAD. These prospective data support a role for IL-8 in the development of CAD events.
|Alternate Journal||Arterioscler. Thromb. Vasc. Biol.|