IL-8 plasma concentrations and the risk of future coronary artery disease in apparently healthy men and women: the EPIC-Norfolk prospective population study.

TitleIL-8 plasma concentrations and the risk of future coronary artery disease in apparently healthy men and women: the EPIC-Norfolk prospective population study.
Publication TypeJournal Article
Year of Publication2004
AuthorsS Boekholdt, M, Peters, RJG, C Hack, E, Day, NE, Luben, R, Bingham, SA, Wareham, NJ, Reitsma, PH, Khaw, K-T
JournalArterioscler Thromb Vasc Biol
Volume24
Issue8
Pagination1503-8
Date Published2004 Aug
ISSN1524-4636
KeywordsAged, Biomarkers, C-Reactive Protein, Case-Control Studies, Cohort Studies, Comorbidity, Coronary Disease, England, Female, Humans, Hypertension, Interleukin-8, Interleukins, Leukocyte Count, Lipids, Lipoproteins, Male, Middle Aged, Obesity, Odds Ratio, Predictive Value of Tests, Prospective Studies, Risk, Risk Factors, Smoking, Tumor Necrosis Factor-alpha
Abstract

OBJECTIVE: To study the role of IL-8 in predicting future coronary artery disease (CAD) in apparently healthy men and women.METHODS AND RESULTS: A nested case-control study was performed in the prospective EPIC-Norfolk population study. We measured baseline IL-8 concentrations among 785 apparently healthy individuals in whom fatal or nonfatal CAD developed during follow-up and 1570 matched controls. Baseline IL-8 concentrations were higher in cases than in matched controls (3.5 pg/mL versus 3.1 pg/mL, P=0.001). The risk of future CAD increased with increasing quartiles of IL-8 (P linearity <0.0001). Among individuals in the highest IL-8 quartile, the unadjusted odds ratio for future CAD was 1.72 (95% CI, 1.34 to 2.21; P<0.0001). The odds ratio for future CAD was still significant after adjustment for traditional risk factors (OR, 1.58; 95%CI, 1.19 to 2.09; P=0.002) and after additional adjustment for C-reactive protein and white cell count (OR, 1.77; 95% CI, 1.21 to 2.60; P=0.001).CONCLUSIONS: We conclude that among apparently healthy men and women, elevated levels of IL-8 are associated with an increased risk of future CAD. These prospective data support a role for IL-8 in the development of CAD events.

DOI10.1161/01.ATV.0000134294.54422.2e
Alternate JournalArterioscler. Thromb. Vasc. Biol.
Citation Key10.1161/01.ATV.0000134294.54422.2e
PubMed ID15178568