Intake of dietary plant sterols is inversely related to serum cholesterol concentration in men and women in the EPIC Norfolk population: a cross-sectional study.

TitleIntake of dietary plant sterols is inversely related to serum cholesterol concentration in men and women in the EPIC Norfolk population: a cross-sectional study.
Publication TypeJournal Article
Year of Publication2004
AuthorsAndersson, SW, Skinner, J, Ellegård, L, Welch, AA, Bingham, S, Mulligan, A, Andersson, H, Khaw, K-T
JournalEur J Clin Nutr
Volume58
Issue10
Pagination1378-85
Date Published2004 Oct
ISSN0954-3007
KeywordsAdult, Aged, Body Mass Index, Cholesterol, Cholesterol, LDL, Cross-Sectional Studies, Female, Health Surveys, Humans, Male, Middle Aged, Phytosterols, Prospective Studies, Sex Characteristics, Surveys and Questionnaires, United Kingdom
Abstract

OBJECTIVE: We examined the relation between intake of natural dietary plant sterols and serum lipid concentrations in a free-living population.DESIGN, SETTING AND PARTICIPANTS: Cross-sectional population-based study of 22,256 men and women aged 39-79 y resident in Norfolk, UK, participating in the European Prospective Investigation into Cancer (EPIC-Norfolk). MAIN EXPOSURE AND OUTCOME MEASURES: Plant sterol intake from foods and concentrations of blood lipids.RESULTS: Mean concentrations of total cholesterol and low-density lipoprotein cholesterol, adjusted for age, body mass index and total energy intake, decreased with increasing plant sterol intake in men and women. Mean total serum cholesterol concentration for men in the highest fifth of plant sterol intake (mean intake 463 mg daily) was 0.25 mmol/l lower and for low-density lipoprotein cholesterol 0.14 mmol/l lower than those in the lowest fifth of plant sterol consumption (mean intake 178 mg daily); the corresponding figures in women were 0.15 and 0.13 mmol/l. After adjusting for saturated fat and fibre intakes, the results for total cholesterol and low-density lipoprotein cholesterol were similar, although the strength of the association was slightly reduced.CONCLUSIONS: In a free-living population, a high intake of plant sterols is inversely associated with lower concentrations of total and low-density lipoprotein serum cholesterol. The plant sterol content of foods may partly explain diet-related effects on serum cholesterol concentration.

DOI10.1038/sj.ejcn.1601980
Alternate JournalEur J Clin Nutr
Citation Key10.1038/sj.ejcn.1601980
PubMed ID15054420