Dietary fat and the risk of clinical type 2 diabetes: the European prospective investigation of Cancer-Norfolk study.

TitleDietary fat and the risk of clinical type 2 diabetes: the European prospective investigation of Cancer-Norfolk study.
Publication TypeJournal Article
Year of Publication2004
AuthorsHarding, A-H, Day, NE, Khaw, K-T, Bingham, S, Luben, R, Welsh, A, Wareham, NJ
JournalAm J Epidemiol
Volume159
Issue1
Pagination73-82
Date Published2004 Jan 01
ISSN0002-9262
KeywordsAdult, Aged, Diabetes Mellitus, Type 2, Diet, Diet Records, Dietary Fats, Dietary Fats, Unsaturated, Europe, Female, Glycated Hemoglobin A, Humans, Male, Middle Aged, Odds Ratio, Prospective Studies, Risk Factors, Surveys and Questionnaires
Abstract

The role of dietary fat in the etiology of type 2 diabetes remains uncertain. The authors investigated the association between dietary fat composition and risk of clinical type 2 diabetes in the European Prospective Investigation of Cancer-Norfolk study and identified food consumption patterns associated with dietary fat composition. Diet was assessed at baseline (1993-1997) using a semiquantitative food frequency questionnaire. From multiple sources of information, 414 incident cases of diabetes were identified among 23,631 men and women aged 40-78 years during 3-7 years of follow-up. The capture-recapture ascertainment level was 99%. The energy-adjusted dietary polyunsaturated:saturated fat ratio was inversely associated with the risk of diabetes (odds ratio (OR) = 0.84 per standard deviation change, 95% confidence interval (CI): 0.75, 0.94). Adjustment for age, sex, family history of diabetes, smoking, physical activity, total fat, protein, and alcohol attenuated the association (OR = 0.88, 95% CI: 0.78, 0.99), and it was no longer statistically significant after including body mass index and the waist:hip ratio (OR = 0.91, 95% CI: 0.81, 1.03). This prospective study showed that an increased dietary polyunsaturated:saturated fat ratio was associated with a reduced risk of diabetes, independent of age, sex, family history of diabetes, and other lifestyle factors.

DOI10.1093/aje/kwh004
Alternate JournalAm. J. Epidemiol.
Citation Key10.1093/aje/kwh004
PubMed ID14693662